Several mucinous cystadenocarcinomas of ovary along with a fraction of tumor cells in a few pancreatic cancers showed strong cytoplasmic positivity. A rare case of urothelial cancer displayed moderate nuclear immunoreactivity. Remaining cancer cells were negative.
BDKRB2 (HGNC Symbol)
Bradykinin receptor B2 (HGNC Symbol)
Entrez gene summary
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]