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BDKRB2

GENERAL INFORMATION

Gene name

 BDKRB2

Gene description

 Bradykinin receptor B2

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (ASC TERT1, BJ hTERT+, U-87 MG)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in a group of tissues, including CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA050841
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA050841

GENE INFORMATION

Gene name

 BDKRB2 (HGNC Symbol)

Synonyms

 BK-2

Description

 Bradykinin receptor B2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q32.2

Chromosome location (bp)

 96204679 - 96244166

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168398 (version 83.38)

Entrez gene

 624

UniProt

 P30411 (UniProt - Evidence at protein level)

neXtProt

 NX_P30411

Antibodypedia

 BDKRB2 antibodies

PROTEIN BROWSER
BDKRB2-001
BDKRB2-002
BDKRB2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BDKRB2-001
ENSP00000450482
ENST00000554311
P30411 [Direct mapping]
B2 bradykinin receptor
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0002020 [protease binding]
GO:0002438 [acute inflammatory response to antigenic stimulus]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004947 [bradykinin receptor activity]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006939 [smooth muscle contraction]
GO:0006954 [inflammatory response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008015 [blood circulation]
GO:0008285 [negative regulation of cell proliferation]
GO:0009651 [response to salt stress]
GO:0016021 [integral component of membrane]
GO:0019229 [regulation of vasoconstriction]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031702 [type 1 angiotensin receptor binding]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0035633 [maintenance of blood-brain barrier]
GO:0042310 [vasoconstriction]
GO:0042311 [vasodilation]
GO:0042493 [response to drug]
GO:0043114 [regulation of vascular permeability]
GO:0045776 [negative regulation of blood pressure]
GO:0046982 [protein heterodimerization activity]
GO:0050482 [arachidonic acid secretion]
GO:0071456 [cellular response to hypoxia]
GO:1902219 [negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress]
GO:1902239 [negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator]
Show all
 391 aa
44.5 kDa 		No 7
BDKRB2-002
ENSP00000438376
ENST00000539359
P30411 [Direct mapping]
B2 bradykinin receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0002020 [protease binding]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004947 [bradykinin receptor activity]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006939 [smooth muscle contraction]
GO:0006954 [inflammatory response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008015 [blood circulation]
GO:0016021 [integral component of membrane]
GO:0019229 [regulation of vasoconstriction]
GO:0031702 [type 1 angiotensin receptor binding]
GO:0042310 [vasoconstriction]
GO:0043114 [regulation of vascular permeability]
GO:0046982 [protein heterodimerization activity]
GO:0050482 [arachidonic acid secretion]
Show all
 364 aa
41.4 kDa 		No 7
BDKRB2-003
ENSP00000439459
ENST00000542454
P30411 [Direct mapping]
B2 bradykinin receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0002020 [protease binding]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0004947 [bradykinin receptor activity]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006939 [smooth muscle contraction]
GO:0006954 [inflammatory response]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0008015 [blood circulation]
GO:0016021 [integral component of membrane]
GO:0019229 [regulation of vasoconstriction]
GO:0031702 [type 1 angiotensin receptor binding]
GO:0042310 [vasoconstriction]
GO:0043114 [regulation of vascular permeability]
GO:0046982 [protein heterodimerization activity]
GO:0050482 [arachidonic acid secretion]
Show all
 364 aa
41.4 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.