Tissue expression of MLKL - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MLKL
Gene description	Mixed lineage kinase domain-like
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	MLKL (HGNC Symbol)
Synonyms	FLJ34389
Description	Mixed lineage kinase domain-like (HGNC Symbol)
Entrez gene summary	This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
Chromosome	16
Cytoband	q23.1
Chromosome location (bp)	74671855 - 74700960
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168404 (version 83.38)
Entrez gene	197259
UniProt	Q8NB16 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NB16
Antibodypedia	MLKL antibodies

PROTEIN BROWSER

MLKL-001	MLKL-002	MLKL-005	MLKL-006	MLKL-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MLKL-001 ENSP00000308351 ENST00000308807	Q8NB16 [Direct mapping] Mixed lineage kinase domain-like protein Show all	Enzymes Kinases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0012501 [programmed cell death] GO:0019901 [protein kinase binding] GO:0032403 [protein complex binding] GO:0070207 [protein homotrimerization] GO:0070266 [necroptotic process] GO:0097300 [programmed necrotic cell death] Show all	471 aa 54.5 kDa	No	0
MLKL-002 ENSP00000303118 ENST00000306247	Q8NB16 [Direct mapping] Mixed lineage kinase domain-like protein Show all	Enzymes Kinases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0012501 [programmed cell death] GO:0032403 [protein complex binding] GO:0070207 [protein homotrimerization] GO:0070266 [necroptotic process] GO:0097300 [programmed necrotic cell death] Show all	263 aa 30.3 kDa	No	0
MLKL-005 ENSP00000459920 ENST00000573267	I3L2T9 [Direct mapping] Mixed lineage kinase domain-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		211 aa 24.8 kDa	No	0
MLKL-006 ENSP00000461666 ENST00000575686	I3L4Z5 [Direct mapping] Mixed lineage kinase domain-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		62 aa 7.2 kDa	No	0
MLKL-008 ENSP00000459935 ENST00000576529	I3L2U3 [Direct mapping] Mixed lineage kinase domain-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0006468 [protein phosphorylation] Show all	102 aa 11.2 kDa	No	0