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COG7

GENERAL INFORMATION

Gene name

 COG7

Gene description

 Component of oligomeric golgi complex 7

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA040758
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (favourable).
0.00.10.20.30.40.50.60.70.80.91.0 0 1 2 3 4 5 6 7 8 910111213141516 Renal cancer p<0.001
0.00.10.20.30.40.50.60.70.80.91.0 0 1 2 3 4 5 6 7 8 9101112131415161718 Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all
0.05.0101520253035FPKMBreast cancer (BRCA)Cervical cancer (CESC)Colorectal cancer (COAD,READ)Endometrial cancer (UCEC)Glioma (GBM)Head and neck cancer (HNSC)Liver cancer (LIHC)Lung cancer (LUAD,LUSC)Melanoma (SKCM)Ovarian cancer (OV)Pancreatic cancer (PAAD)Prostate cancer (PRAD)Renal cancer (KICH,KIRC,KIRP)Stomach cancer (STAD)Testis cancer (TGCT)Thyroid cancer (THCA)Urothelial cancer (BLCA)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040758

Cancer

Cancer staining

Protein
expression of
normal tissue
Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue
Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

 Most endometrial and liver cancers along with several carcinoids, gliomas, colorectal, breast, urothelial and pancreatic cancers exhibited moderate to strong cytoplasmic positivity. Remaining tumor were in general weakly stained or negative.

GENE INFORMATION

Gene name

 COG7

Synonyms

Description

 Component of oligomeric golgi complex 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene resides in the golgi, and constitutes one of the 8 subunits of the conserved oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Mutations in this gene are associated with the congenital disorder of glycosylation type IIe.[provided by RefSeq, May 2010]

Chromosome

 16

Cytoband

 p12.2

Chromosome location (bp)

 23388493 - 23453180

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168434 (version 83.38)

Entrez gene

 91949

UniProt

 P83436 (UniProt - Evidence at protein level)

neXtProt

 NX_P83436

Antibodypedia

 COG7 antibodies

PROTEIN BROWSER
COG7-001
COG7-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COG7-001
ENSP00000305442
ENST00000307149
P83436 [Direct mapping]
Conserved oligomeric Golgi complex subunit 7
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0006486 [protein glycosylation]
GO:0006886 [intracellular protein transport]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0007030 [Golgi organization]
GO:0017119 [Golgi transport complex]
GO:0033365 [protein localization to organelle]
GO:0034067 [protein localization to Golgi apparatus]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0050821 [protein stabilization]
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 770 aa
86.3 kDa 		No 0
COG7-005
ENSP00000460151
ENST00000563164
I3L337 [Direct mapping]
Conserved oligomeric Golgi complex subunit 7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006886 [intracellular protein transport]
GO:0017119 [Golgi transport complex]
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 113 aa
12 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.