Expression of SCNN1B in cancer - Summary - The Human Protein Atlas

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SCNN1B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SCNN1B
Gene description	Sodium channel, non voltage gated 1 beta subunit
Protein class	Disease related genes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (urothelial cancer)
HPA (cell line):	Cell line enhanced (hTCEpi, RT4, U-266/70, U-266/84)
HPA (normal tissue):	Tissue enhanced (cervix, uterine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA015612
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (urothelial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA015612

GENE INFORMATION
Gene name	SCNN1B (HGNC Symbol)
Synonyms	ENaCbeta
Description	Sodium channel, non voltage gated 1 beta subunit (HGNC Symbol)
Entrez gene summary	Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome. [provided by RefSeq, Apr 2009]
Chromosome	16
Cytoband	p12.2
Chromosome location (bp)	23278231 - 23381299
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168447 (version 83.38)
Entrez gene	6338
UniProt	P51168 (UniProt - Evidence at protein level)
neXtProt	NX_P51168
Antibodypedia	SCNN1B antibodies

PROTEIN BROWSER

SCNN1B-001	SCNN1B-002	SCNN1B-004	SCNN1B-006	SCNN1B-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCNN1B-001 ENSP00000345751 ENST00000343070	P51168 [Direct mapping] Amiloride-sensitive sodium channel subunit beta B2R812 [Target identity:100%; Query identity:100%] Amiloride-sensitive sodium channel subunit beta 1; Sodium channel, nonvoltage-gated 1, beta (Liddle syndrome), isoform CRA_b; cDNA, FLJ93691, highly similar to Homo sapiens sodium channel, nonvoltage-gated 1, beta (Liddle syndrome) (SCNN1B), mRNA Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0001666 [response to hypoxia] GO:0002028 [regulation of sodium ion transport] GO:0005272 [sodium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006814 [sodium ion transport] GO:0007588 [excretion] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0015280 [ligand-gated sodium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030659 [cytoplasmic vesicle membrane] GO:0034220 [ion transmembrane transport] GO:0034706 [sodium channel complex] GO:0035313 [wound healing, spreading of epidermal cells] GO:0035725 [sodium ion transmembrane transport] GO:0050699 [WW domain binding] GO:0050891 [multicellular organismal water homeostasis] GO:0050909 [sensory perception of taste] GO:0055078 [sodium ion homeostasis] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	640 aa 72.7 kDa	No	2
SCNN1B-002 ENSP00000302874 ENST00000307331	P51168 [Direct mapping] Amiloride-sensitive sodium channel subunit beta Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0005272 [sodium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006814 [sodium ion transport] GO:0007588 [excretion] GO:0015280 [ligand-gated sodium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030659 [cytoplasmic vesicle membrane] GO:0034220 [ion transmembrane transport] GO:0034706 [sodium channel complex] GO:0035725 [sodium ion transmembrane transport] GO:0050699 [WW domain binding] GO:0050891 [multicellular organismal water homeostasis] GO:0050909 [sensory perception of taste] GO:0055078 [sodium ion homeostasis] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] Show all	685 aa 77.7 kDa	No	2
SCNN1B-004 ENSP00000482681 ENST00000566441	A0A087WZI2 [Direct mapping] Amiloride-sensitive sodium channel subunit beta Show all	Predicted intracellular proteins Show all	GO:0005272 [sodium channel activity] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] Show all	188 aa 20.6 kDa	No	0
SCNN1B-006 ENSP00000455673 ENST00000568085	H3BQ95 [Direct mapping] Amiloride-sensitive sodium channel subunit beta Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005272 [sodium channel activity] GO:0006814 [sodium ion transport] GO:0015280 [ligand-gated sodium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] Show all	604 aa 68.5 kDa	No	2
SCNN1B-007 ENSP00000456309 ENST00000568923	H3BRM4 [Direct mapping] Amiloride-sensitive sodium channel subunit beta Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005272 [sodium channel activity] GO:0006814 [sodium ion transport] GO:0015280 [ligand-gated sodium channel activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] Show all	613 aa 69.5 kDa	No	2

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