Expression of SFTPC in cancer - Summary - The Human Protein Atlas

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SFTPC

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SFTPC
Gene description	Surfactant protein C
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (lung cancer)
HPA (cell line):	Group enriched (BEWO, NB-4, SCLC-21H, U-2197)
HPA (normal tissue):	Tissue enriched (lung)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in pneumocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA010928 , CAB009313
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (lung cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA010928	CAB009313

GENE INFORMATION
Gene name	SFTPC (HGNC Symbol)
Synonyms	BRICD6, PSP-C, SFTP2, SMDP2, SP-C
Description	Surfactant protein C (HGNC Symbol)
Entrez gene summary	This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010]
Chromosome	8
Cytoband	p21.3
Chromosome location (bp)	22156913 - 22164479
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168484 (version 83.38)
Entrez gene	6440
UniProt	P11686 (UniProt - Evidence at protein level)
neXtProt	NX_P11686
Antibodypedia	SFTPC antibodies

PROTEIN BROWSER

SFTPC-001	SFTPC-003	SFTPC-006	SFTPC-007	SFTPC-008	SFTPC-010	SFTPC-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SFTPC-001 ENSP00000316152 ENST00000318561	P11686 [Direct mapping] Pulmonary surfactant-associated protein C Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0007585 [respiratory gaseous exchange] GO:0042599 [lamellar body] GO:0044267 [cellular protein metabolic process] GO:0045334 [clathrin-coated endocytic vesicle] GO:0097486 [multivesicular body lumen] Show all	197 aa 21 kDa	No	0
SFTPC-003 ENSP00000430410 ENST00000521315	A0A0A0MTC9 [Direct mapping] Pulmonary surfactant-associated protein C Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005576 [extracellular region] GO:0007585 [respiratory gaseous exchange] GO:0016021 [integral component of membrane] Show all	191 aa 20.3 kDa	No	0
SFTPC-006 ENSP00000430266 ENST00000520605	E5RG20 [Direct mapping] Pulmonary surfactant-associated protein C Show all	Predicted intracellular proteins Show all	GO:0005576 [extracellular region] GO:0007585 [respiratory gaseous exchange] Show all	155 aa 17.4 kDa	No	0
SFTPC-007 ENSP00000429552 ENST00000524255	E5RI64 [Direct mapping] Pulmonary surfactant-associated protein C Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005576 [extracellular region] GO:0007585 [respiratory gaseous exchange] Show all	144 aa 15.3 kDa	No	0
SFTPC-008 ENSP00000429619 ENST00000523296	E5RHW5 [Direct mapping] Pulmonary surfactant-associated protein C Show all	Predicted intracellular proteins Show all	GO:0005576 [extracellular region] GO:0007585 [respiratory gaseous exchange] Show all	125 aa 13.1 kDa	No	0
SFTPC-010 ENSP00000429496 ENST00000522109	E5RI92 [Direct mapping] Pulmonary surfactant-associated protein C Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0005576 [extracellular region] GO:0007585 [respiratory gaseous exchange] GO:0016021 [integral component of membrane] Show all	150 aa 16.2 kDa	No	0
SFTPC-011 ENSP00000407931 ENST00000437090	C9JYF6 [Direct mapping] Pulmonary surfactant-associated protein C Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0005576 [extracellular region] GO:0007585 [respiratory gaseous exchange] GO:0016021 [integral component of membrane] Show all	161 aa 17.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.