Cell atlas - BMP1 - The Human Protein Atlas

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BMP1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	BMP1
Gene description	Bone morphogenetic protein 1
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	BMP1 (HGNC Symbol)
Synonyms	PCOLC
Description	Bone morphogenetic protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008]
Chromosome	8
Cytoband	p21.3
Chromosome location (bp)	22164736 - 22212326
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168487 (version 83.38)
Entrez gene	649
UniProt	P13497 (UniProt - Evidence at protein level)
neXtProt	NX_P13497
Antibodypedia	BMP1 antibodies

PROTEIN BROWSER

BMP1-001	BMP1-010	BMP1-201	BMP1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BMP1-001 ENSP00000305714 ENST00000306385	P13497 [Direct mapping] Bone morphogenetic protein 1 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0001502 [cartilage condensation] GO:0001503 [ossification] GO:0004222 [metalloendopeptidase activity] GO:0005125 [cytokine activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0007275 [multicellular organismal development] GO:0008083 [growth factor activity] GO:0008233 [peptidase activity] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0022617 [extracellular matrix disassembly] GO:0030154 [cell differentiation] GO:0030198 [extracellular matrix organization] GO:0031988 [membrane-bounded vesicle] GO:0042157 [lipoprotein metabolic process] GO:0044281 [small molecule metabolic process] GO:0061036 [positive regulation of cartilage development] Show all	986 aa 111.2 kDa	Yes	0
BMP1-010 ENSP00000306121 ENST00000306349	P13497 [Direct mapping] Bone morphogenetic protein 1 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0001502 [cartilage condensation] GO:0001503 [ossification] GO:0004222 [metalloendopeptidase activity] GO:0005125 [cytokine activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0007275 [multicellular organismal development] GO:0008083 [growth factor activity] GO:0008233 [peptidase activity] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0022617 [extracellular matrix disassembly] GO:0030154 [cell differentiation] GO:0030198 [extracellular matrix organization] GO:0042157 [lipoprotein metabolic process] GO:0044281 [small molecule metabolic process] GO:0061036 [positive regulation of cartilage development] Show all	730 aa 82.9 kDa	Yes	0
BMP1-201 ENSP00000346941 ENST00000354870	Q3MIM8 [Direct mapping] Metalloendopeptidase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	302 aa 33.4 kDa	Yes	0
BMP1-202 ENSP00000380915 ENST00000397814	B7ZKR5 [Direct mapping] BMP1 protein; Bone morphogenetic protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] Show all	189 aa 21 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.