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FNTA

GENERAL INFORMATION

Gene name

 FNTA

Gene description

 Farnesyltransferase, CAAX box, alpha

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA018830 , CAB010149
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018830
CAB010149

GENE INFORMATION

Gene name

 FNTA (HGNC Symbol)

Synonyms

 FPTA, PGGT1A, PTAR2

Description

 Farnesyltransferase, CAAX box, alpha (HGNC Symbol)

Entrez gene summary

 Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]

Chromosome

 8

Cytoband

 p11.21

Chromosome location (bp)

 43034194 - 43085788

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168522 (version 83.38)

Entrez gene

 2339

UniProt

 P49354 (UniProt - Evidence at protein level)

neXtProt

 NX_P49354

Antibodypedia

 FNTA antibodies

PROTEIN BROWSER
FNTA-001
FNTA-004
FNTA-007
FNTA-008
FNTA-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FNTA-001
ENSP00000303423
ENST00000302279
P49354 [Direct mapping]
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004660 [protein farnesyltransferase activity]
GO:0004661 [protein geranylgeranyltransferase activity]
GO:0004662 [CAAX-protein geranylgeranyltransferase activity]
GO:0004663 [Rab geranylgeranyltransferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005875 [microtubule associated complex]
GO:0005953 [CAAX-protein geranylgeranyltransferase complex]
GO:0005965 [protein farnesyltransferase complex]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007528 [neuromuscular junction development]
GO:0007603 [phototransduction, visible light]
GO:0008017 [microtubule binding]
GO:0008318 [protein prenyltransferase activity]
GO:0010469 [regulation of receptor activity]
GO:0012501 [programmed cell death]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0018342 [protein prenylation]
GO:0018343 [protein farnesylation]
GO:0018344 [protein geranylgeranylation]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030548 [acetylcholine receptor regulator activity]
GO:0030971 [receptor tyrosine kinase binding]
GO:0043014 [alpha-tubulin binding]
GO:0045213 [neurotransmitter receptor metabolic process]
GO:0071340 [skeletal muscle acetylcholine-gated channel clustering]
GO:0090044 [positive regulation of tubulin deacetylation]
GO:0090045 [positive regulation of deacetylase activity]
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 379 aa
44.4 kDa 		No 0
FNTA-004
ENSP00000473479
ENST00000529687
B3KVN2 [Direct mapping]
Farnesyltransferase, CAAX box, alpha, isoform CRA_c; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; cDNA FLJ16794 fis, clone TBAES2007504, highly similar to Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit (EC 2.5.1.58)
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008318 [protein prenyltransferase activity]
GO:0018342 [protein prenylation]
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 228 aa
27.4 kDa 		No 0
FNTA-007
ENSP00000434430
ENST00000533336
E9PQP6 [Direct mapping]
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008318 [protein prenyltransferase activity]
GO:0018342 [protein prenylation]
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 249 aa
30.1 kDa 		No 0
FNTA-008
ENSP00000432411
ENST00000531266
H0YCW1 [Direct mapping]
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008318 [protein prenyltransferase activity]
GO:0018342 [protein prenylation]
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 197 aa
23 kDa 		No 0
FNTA-009
ENSP00000436998
ENST00000525699
E9PPM9 [Direct mapping]
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008318 [protein prenyltransferase activity]
GO:0018342 [protein prenylation]
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 60 aa
7.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.