Expression of SERINC2 in cancer - Summary - The Human Protein Atlas

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SERINC2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SERINC2
Gene description	Serine incorporator 2
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (CAPAN-2, HaCaT, RT4)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA005974
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), liver cancer (unfavourable) and lung cancer (unfavourable).
Endometrial cancer p<0.001 Liver cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA005974

GENE INFORMATION
Gene name	SERINC2 (HGNC Symbol)
Synonyms	FKSG84, PRO0899, TDE2, TDE2L
Description	Serine incorporator 2 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p35.2
Chromosome location (bp)	31409565 - 31434680
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168528 (version 83.38)
Entrez gene	347735
UniProt	Q96SA4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96SA4
Antibodypedia	SERINC2 antibodies

PROTEIN BROWSER

SERINC2-001	SERINC2-002	SERINC2-201	SERINC2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERINC2-001 ENSP00000362813 ENST00000373709	Q96SA4 [Direct mapping] Serine incorporator 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006665 [sphingolipid metabolic process] GO:0015194 [L-serine transmembrane transporter activity] GO:0015825 [L-serine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	455 aa 50.7 kDa	Yes	>9
SERINC2-002 ENSP00000362814 ENST00000373710	Q96SA4 [Direct mapping] Serine incorporator 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006658 [phosphatidylserine metabolic process] GO:0006665 [sphingolipid metabolic process] GO:0015194 [L-serine transmembrane transporter activity] GO:0015825 [L-serine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] GO:1904219 [positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity] GO:1904222 [positive regulation of serine C-palmitoyltransferase activity] Show all	464 aa 52.1 kDa	No	>9
SERINC2-201 ENSP00000439048 ENST00000536384	Q96SA4 [Direct mapping] Serine incorporator 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006665 [sphingolipid metabolic process] GO:0015194 [L-serine transmembrane transporter activity] GO:0015825 [L-serine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	459 aa 51.4 kDa	No	>9
SERINC2-202 ENSP00000444307 ENST00000536859	Q96SA4 [Direct mapping] Serine incorporator 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006665 [sphingolipid metabolic process] GO:0015194 [L-serine transmembrane transporter activity] GO:0015825 [L-serine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	459 aa 51.5 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.