Expression of MYL1 in cancer - Summary - The Human Protein Atlas

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MYL1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MYL1
Gene description	Myosin, light chain 1, alkali; skeletal, fast
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (head and neck cancer, prostate cancer)
HPA (cell line):	Cell line enriched (RH-30)
HPA (normal tissue):	Tissue enriched (skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in skeletal muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 2 antibodies. HPA046859 , HPA063034
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable).
Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (head and neck cancer, prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046859	HPA063034

GENE INFORMATION
Gene name	MYL1
Synonyms
Description	Myosin, light chain 1, alkali; skeletal, fast (HGNC Symbol)
Entrez gene summary	Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q34
Chromosome location (bp)	210290150 - 210315190
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168530 (version 83.38)
Entrez gene	4632
UniProt	P05976 (UniProt - Evidence at transcript level)
neXtProt	NX_P05976
Antibodypedia	MYL1 antibodies

PROTEIN BROWSER

MYL1-001	MYL1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYL1-001 ENSP00000307280 ENST00000352451	P05976 [Direct mapping] Myosin light chain 1/3, skeletal muscle isoform Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005829 [cytosol] GO:0005859 [muscle myosin complex] GO:0006936 [muscle contraction] GO:0008307 [structural constituent of muscle] GO:0030016 [myofibril] GO:0030017 [sarcomere] GO:0030049 [muscle filament sliding] GO:0043292 [contractile fiber] GO:0060048 [cardiac muscle contraction] Show all	194 aa 21.1 kDa	Yes	0
MYL1-002 ENSP00000343321 ENST00000341685	P05976 [Direct mapping] Myosin light chain 1/3, skeletal muscle isoform Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005829 [cytosol] GO:0005859 [muscle myosin complex] GO:0006936 [muscle contraction] GO:0008307 [structural constituent of muscle] GO:0030016 [myofibril] GO:0030017 [sarcomere] GO:0030049 [muscle filament sliding] Show all	150 aa 16.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.