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CHRM1

GENERAL INFORMATION

Gene name

 CHRM1

Gene description

 Cholinergic receptor, muscarinic 1

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (prostate cancer)
HPA (cell line):Cell line enhanced (MCF7, SK-BR-3, T-47d)
HPA (normal tissue):Group enriched (cerebral cortex, prostate, salivary gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in pyramidal neurons and Purkinje cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Supported based on 1 antibody.
HPA014101
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (prostate cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA014101

GENE INFORMATION

Gene name

 CHRM1

Synonyms

Description

 Cholinergic receptor, muscarinic 1 (HGNC Symbol)

Entrez gene summary

 The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q12.3

Chromosome location (bp)

 62908679 - 62921807

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168539 (version 83.38)

Entrez gene

 1128

UniProt

 P11229 (UniProt - Evidence at protein level)

neXtProt

 NX_P11229

Antibodypedia

 CHRM1 antibodies

PROTEIN BROWSER
CHRM1-001
CHRM1-002
CHRM1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHRM1-001
ENSP00000306490
ENST00000306960
P11229 [Direct mapping]
Muscarinic acetylcholine receptor M1
Q53XZ3 [Target identity:100%; Query identity:100%]
Muscarinic acetylcholine receptor
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006464 [cellular protein modification process]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007197 [adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007207 [phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway]
GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007274 [neuromuscular synaptic transmission]
GO:0007399 [nervous system development]
GO:0007603 [phototransduction, visible light]
GO:0007606 [sensory perception of chemical stimulus]
GO:0008144 [drug binding]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0009649 [entrainment of circadian clock]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016907 [G-protein coupled acetylcholine receptor activity]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0032279 [asymmetric synapse]
GO:0040012 [regulation of locomotion]
GO:0043270 [positive regulation of ion transport]
GO:0043679 [axon terminus]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0046541 [saliva secretion]
GO:0050890 [cognition]
GO:0090316 [positive regulation of intracellular protein transport]
Show all
 460 aa
51.4 kDa 		No 7
CHRM1-002
ENSP00000441188
ENST00000543973
P11229 [Direct mapping]
Muscarinic acetylcholine receptor M1
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006464 [cellular protein modification process]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007197 [adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007207 [phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway]
GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007399 [nervous system development]
GO:0007603 [phototransduction, visible light]
GO:0007606 [sensory perception of chemical stimulus]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0009649 [entrainment of circadian clock]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0043270 [positive regulation of ion transport]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0046541 [saliva secretion]
GO:0050890 [cognition]
Show all
 454 aa
50.7 kDa 		No 7
CHRM1-003
ENSP00000444482
ENST00000536524
F5GZF8 [Direct mapping]
Muscarinic acetylcholine receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007197 [adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway]
GO:0007271 [synaptic transmission, cholinergic]
GO:0007606 [sensory perception of chemical stimulus]
GO:0016021 [integral component of membrane]
GO:0016907 [G-protein coupled acetylcholine receptor activity]
GO:0030054 [cell junction]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
Show all
 134 aa
14.6 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.