Expression of SNRNP48 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SNRNP48

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SNRNP48
Gene description	Small nuclear ribonucleoprotein 48kDa (U11/U12)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA029234
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and breast cancer (unfavourable).
Renal cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029234

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Most cancer tissues displayed weak to moderate nuclear immunoreactivity. Strong positivity was displayed in several gliomas while renal cancers were generally negative.

GENE INFORMATION
Gene name	SNRNP48 (HGNC Symbol)
Synonyms	C6orf151, dJ336K20B.1, dJ512B11.2, FLJ32234
Description	Small nuclear ribonucleoprotein 48kDa (U11/U12) (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	p24.3
Chromosome location (bp)	7590199 - 7611967
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168566 (version 83.38)
Entrez gene	154007
UniProt	Q6IEG0 (UniProt - Evidence at protein level)
neXtProt	NX_Q6IEG0
Antibodypedia	SNRNP48 antibodies

PROTEIN BROWSER

SNRNP48-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SNRNP48-001 ENSP00000339834 ENST00000342415	Q6IEG0 [Direct mapping] U11/U12 small nuclear ribonucleoprotein 48 kDa protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0005654 [nucleoplasm] GO:0005689 [U12-type spliceosomal complex] GO:0005737 [cytoplasm] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0046872 [metal ion binding] Show all	339 aa 40 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.