Tissue expression of ADAM9 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ADAM9
Gene description	ADAM metallopeptidase domain 9
Protein class	Cancer-related genes Disease related genes Enzymes Plasma proteins Potential drug targets Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ADAM9 (HGNC Symbol)
Synonyms	CORD9, KIAA0021, MCMP, MDC9, Mltng
Description	ADAM metallopeptidase domain 9 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]
Chromosome	8
Cytoband	p11.22
Chromosome location (bp)	38996869 - 39105144
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168615 (version 83.38)
Entrez gene	8754
UniProt	Q13443 (UniProt - Evidence at protein level)
neXtProt	NX_Q13443
Antibodypedia	ADAM9 antibodies

PROTEIN BROWSER

ADAM9-001	ADAM9-002	ADAM9-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAM9-001 ENSP00000419446 ENST00000487273	Q13443 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 9 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000186 [activation of MAPKK activity] GO:0004222 [metalloendopeptidase activity] GO:0005080 [protein kinase C binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006508 [proteolysis] GO:0006509 [membrane protein ectodomain proteolysis] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007229 [integrin-mediated signaling pathway] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0009986 [cell surface] GO:0010042 [response to manganese ion] GO:0016021 [integral component of membrane] GO:0017124 [SH3 domain binding] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030216 [keratinocyte differentiation] GO:0030574 [collagen catabolic process] GO:0031233 [intrinsic component of external side of plasma membrane] GO:0033627 [cell adhesion mediated by integrin] GO:0033630 [positive regulation of cell adhesion mediated by integrin] GO:0033631 [cell-cell adhesion mediated by integrin] GO:0034241 [positive regulation of macrophage fusion] GO:0034612 [response to tumor necrosis factor] GO:0042117 [monocyte activation] GO:0042542 [response to hydrogen peroxide] GO:0043236 [laminin binding] GO:0050714 [positive regulation of protein secretion] GO:0051044 [positive regulation of membrane protein ectodomain proteolysis] GO:0051088 [PMA-inducible membrane protein ectodomain proteolysis] GO:0051384 [response to glucocorticoid] GO:0051549 [positive regulation of keratinocyte migration] GO:0051592 [response to calcium ion] GO:0070062 [extracellular exosome] GO:0071222 [cellular response to lipopolysaccharide] Show all	819 aa 90.6 kDa	Yes	1
ADAM9-002 ENSP00000417066 ENST00000481513	C9J6H5 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 9 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	128 aa 14.7 kDa	Yes	0
ADAM9-003 ENSP00000420257 ENST00000466936	C9JPM3 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 9 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] Show all	147 aa 16.8 kDa	Yes	0