Tissue expression of IL7R - Summary - The Human Protein Atlas

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IL7R

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	IL7R
Gene description	Interleukin 7 receptor
Protein class	Cancer-related genes CD markers Disease related genes Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Group enriched (lung, small intestine, spleen)
FANTOM5:	Tissue enhanced (lymph node)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in several tissues, including subsets of immune cells.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. CAB010215
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (lung, small intestine, spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lymph node)

GENE INFORMATION
Gene name	IL7R (HGNC Symbol)
Synonyms	CD127
Description	Interleukin 7 receptor (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2014]
Chromosome	5
Cytoband	p13.2
Chromosome location (bp)	35852695 - 35879603
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168685 (version 83.38)
Entrez gene	3575
UniProt	P16871 (UniProt - Evidence at protein level)
neXtProt	NX_P16871
Antibodypedia	IL7R antibodies

PROTEIN BROWSER

IL7R-001	IL7R-003	IL7R-004	IL7R-006	IL7R-007	IL7R-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL7R-001 ENSP00000306157 ENST00000303115	P16871 [Direct mapping] Interleukin-7 receptor subunit alpha Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000018 [regulation of DNA recombination] GO:0000902 [cell morphogenesis] GO:0001915 [negative regulation of T cell mediated cytotoxicity] GO:0002377 [immunoglobulin production] GO:0003823 [antigen binding] GO:0004896 [cytokine receptor activity] GO:0004917 [interleukin-7 receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0008361 [regulation of cell size] GO:0009897 [external side of plasma membrane] GO:0010628 [positive regulation of gene expression] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016049 [cell growth] GO:0030217 [T cell differentiation] GO:0033089 [positive regulation of T cell differentiation in thymus] GO:0038111 [interleukin-7-mediated signaling pathway] GO:0042100 [B cell proliferation] GO:0048535 [lymph node development] GO:0048872 [homeostasis of number of cells] Show all	459 aa 51.6 kDa	Yes	1
IL7R-003 ENSP00000421207 ENST00000506850	D6RGV2 [Direct mapping] Interleukin-7 receptor subunit alpha Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	261 aa 29.9 kDa	Yes	0
IL7R-004 ENSP00000426426 ENST00000508941	D6RG28 [Direct mapping] Interleukin-7 receptor subunit alpha Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all		59 aa 6.4 kDa	Yes	0
IL7R-006 ENSP00000425538 ENST00000515665	D6RCR9 [Direct mapping] Interleukin-7 receptor subunit alpha Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all		52 aa 5.6 kDa	Yes	0
IL7R-007 ENSP00000425309 ENST00000511982	D6RDM4 [Direct mapping] Interleukin-7 receptor subunit alpha Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all		150 aa 16.8 kDa	Yes	0
IL7R-010 ENSP00000426069 ENST00000505093	H0YA41 [Direct mapping] Interleukin-7 receptor subunit alpha Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	65 aa 7.7 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.