Expression of LRP1B in cancer - Summary - The Human Protein Atlas

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LRP1B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LRP1B
Gene description	Low density lipoprotein receptor-related protein 1B
Protein class	Cancer-related genes Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Cell line enhanced (HEK93, U-138 MG)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in thyroid and CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA069094
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA069094

GENE INFORMATION
Gene name	LRP1B (HGNC Symbol)
Synonyms	LRP-DIT, LRPDIT
Description	Low density lipoprotein receptor-related protein 1B (HGNC Symbol)
Entrez gene summary	LRP1B belongs to the low density lipoprotein (LDL) receptor gene family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands (Liu et al., 2001 [PubMed 11384978]).[supplied by OMIM, Mar 2008]
Chromosome	2
Cytoband
Chromosome location (bp)	140231423 - 142131701
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168702 (version 83.38)
Entrez gene	53353
UniProt	Q9NZR2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NZR2
Antibodypedia	LRP1B antibodies

PROTEIN BROWSER

LRP1B-001	LRP1B-002	LRP1B-003	LRP1B-005	LRP1B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRP1B-001 ENSP00000374135 ENST00000389484	Q9NZR2 [Direct mapping] Low-density lipoprotein receptor-related protein 1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001701 [in utero embryonic development] GO:0005041 [low-density lipoprotein receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0006898 [receptor-mediated endocytosis] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0043235 [receptor complex] Show all	4599 aa 515.5 kDa	Yes	1
LRP1B-002 ENSP00000413239 ENST00000434794	E7ERG8 [Direct mapping] Low-density lipoprotein receptor-related protein 1B Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	782 aa 87.2 kDa	Yes	0
LRP1B-003 ENSP00000415052 ENST00000437977	H0Y7T7 [Direct mapping] Low-density lipoprotein receptor-related protein 1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	798 aa 89.1 kDa	No	1
LRP1B-005 ENSP00000393859 ENST00000442974	H7C0A8 [Direct mapping] Low-density lipoprotein receptor-related protein 1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	280 aa 30.6 kDa	No	1
LRP1B-201 ENSP00000478868 ENST00000618808	A0A087WUR9 [Direct mapping] Low-density lipoprotein receptor-related protein 1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	4406 aa 494.6 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.