Fields »
ABOUT
HELP
BLOG
AHCYL1

GENERAL INFORMATION

Gene name

 AHCYL1

Gene description

 Adenosylhomocysteinase-like 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA042589
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042589

GENE INFORMATION

Gene name

 AHCYL1 (HGNC Symbol)

Synonyms

 IRBIT, PPP1R78, XPVKONA

Description

 Adenosylhomocysteinase-like 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Chromosome

 1

Cytoband

 p13.3

Chromosome location (bp)

 109984686 - 110023741

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168710 (version 83.38)

Entrez gene

 10768

UniProt

 O43865 (UniProt - Evidence at protein level)

neXtProt

 NX_O43865

Antibodypedia

 AHCYL1 antibodies

PROTEIN BROWSER
AHCYL1-001
AHCYL1-002
AHCYL1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AHCYL1-001
ENSP00000358814
ENST00000369799
O43865 [Direct mapping]
Adenosylhomocysteinase 2
A0A024R0A8 [Target identity:100%; Query identity:100%]
Adenosylhomocysteinase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0004013 [adenosylhomocysteinase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006378 [mRNA polyadenylation]
GO:0006611 [protein export from nucleus]
GO:0006730 [one-carbon metabolic process]
GO:0008150 [biological_process]
GO:0010765 [positive regulation of sodium ion transport]
GO:0016324 [apical plasma membrane]
GO:0031440 [regulation of mRNA 3'-end processing]
GO:0032412 [regulation of ion transmembrane transporter activity]
GO:0033353 [S-adenosylmethionine cycle]
GO:0038166 [angiotensin-activated signaling pathway]
GO:0042045 [epithelial fluid transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044070 [regulation of anion transport]
GO:0051592 [response to calcium ion]
GO:0070062 [extracellular exosome]
Show all
 530 aa
59 kDa 		No 0
AHCYL1-002
ENSP00000352092
ENST00000359172
O43865 [Direct mapping]
Adenosylhomocysteinase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0004013 [adenosylhomocysteinase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006378 [mRNA polyadenylation]
GO:0006730 [one-carbon metabolic process]
GO:0008150 [biological_process]
GO:0010765 [positive regulation of sodium ion transport]
GO:0016324 [apical plasma membrane]
GO:0031440 [regulation of mRNA 3'-end processing]
GO:0032412 [regulation of ion transmembrane transporter activity]
GO:0033353 [S-adenosylmethionine cycle]
GO:0038166 [angiotensin-activated signaling pathway]
GO:0051592 [response to calcium ion]
GO:0070062 [extracellular exosome]
Show all
 483 aa
53.8 kDa 		No 0
AHCYL1-201
ENSP00000377238
ENST00000393614
O43865 [Direct mapping]
Adenosylhomocysteinase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0004013 [adenosylhomocysteinase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006378 [mRNA polyadenylation]
GO:0006730 [one-carbon metabolic process]
GO:0008150 [biological_process]
GO:0010765 [positive regulation of sodium ion transport]
GO:0016324 [apical plasma membrane]
GO:0031440 [regulation of mRNA 3'-end processing]
GO:0032412 [regulation of ion transmembrane transporter activity]
GO:0033353 [S-adenosylmethionine cycle]
GO:0038166 [angiotensin-activated signaling pathway]
GO:0051592 [response to calcium ion]
GO:0070062 [extracellular exosome]
Show all
 483 aa
53.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.