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CA7

GENERAL INFORMATION

Gene name

 CA7

Gene description

 Carbonic anhydrase VII

Protein class

 Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (colorectal cancer)
HPA (cell line):Cell line enhanced (REH, SCLC-21H, THP-1)
HPA (normal tissue):Tissue enhanced (colon, rectum)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results.

Reliability score

 Uncertain based on 1 antibody.
HPA047237
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (colorectal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047237

GENE INFORMATION

Gene name

 CA7

Synonyms

Description

 Carbonic anhydrase VII (HGNC Symbol)

Entrez gene summary

 Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 66844379 - 66854153

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168748 (version 83.38)

Entrez gene

 766

UniProt

 P43166 (UniProt - Evidence at protein level)

neXtProt

 NX_P43166

Antibodypedia

 CA7 antibodies

PROTEIN BROWSER
CA7-001
CA7-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CA7-001
ENSP00000345659
ENST00000338437
P43166 [Direct mapping]
Carbonic anhydrase 7
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Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002230 [positive regulation of defense response to virus by host]
GO:0004089 [carbonate dehydratase activity]
GO:0005829 [cytosol]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
GO:0015701 [bicarbonate transport]
GO:0032230 [positive regulation of synaptic transmission, GABAergic]
GO:0032849 [positive regulation of cellular pH reduction]
GO:0044281 [small molecule metabolic process]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:2001225 [regulation of chloride transport]
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 264 aa
29.7 kDa 		No 0
CA7-002
ENSP00000377632
ENST00000394069
P43166 [Direct mapping]
Carbonic anhydrase 7
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Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002230 [positive regulation of defense response to virus by host]
GO:0004089 [carbonate dehydratase activity]
GO:0005829 [cytosol]
GO:0006730 [one-carbon metabolic process]
GO:0008270 [zinc ion binding]
GO:0015701 [bicarbonate transport]
GO:0044281 [small molecule metabolic process]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 208 aa
23.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.