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Cytoplasmic expression in several cell types. Distinct expression in cilia in fallopian tube and respiratory epithelia.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data. Pending external verification. Protein expression in respiratory epithelia can be correlated with lung RNA-seq data.
A fraction of tumor cells in several endometrial cancers and low grade non-Hodgkins lymphomas exhibited moderate to strong cytoplasmic positivity. Rare case of embryonal carcinoma of testis showed strong cytoplasmic staining. Remaining malignancies were generally negative.
GENE INFORMATION
Gene name
TCTN2 (HGNC Symbol)
Synonyms
C12orf38, FLJ12975, MKS8, TECT2
Description
Tectonic family member 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a type I membrane protein that belongs to the tectonic family. Studies in mice suggest that this protein may be involved in hedgehog signaling, and essential for ciliogenesis. Mutations in this gene are associated with Meckel syndrome type 8. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]