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STX18

GENERAL INFORMATION

Gene name

 STX18

Gene description

 Syntaxin 18

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA003019
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), colorectal cancer (favourable), urothelial cancer (favourable) and renal cancer (favourable).
Endometrial cancer p<0.001
Colorectal cancer p<0.001
Urothelial cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003019

GENE INFORMATION

Gene name

 STX18 (HGNC Symbol)

Synonyms

 Ufe1

Description

 Syntaxin 18 (HGNC Symbol)

Entrez gene summary

Chromosome

 4

Cytoband

Chromosome location (bp)

 4415742 - 4542346

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168818 (version 83.38)

Entrez gene

 53407

UniProt

 Q9P2W9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P2W9

Antibodypedia

 STX18 antibodies

PROTEIN BROWSER
STX18-001
STX18-002
STX18-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STX18-001
ENSP00000305810
ENST00000306200
Q9P2W9 [Direct mapping]
Syntaxin-18
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006886 [intracellular protein transport]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019904 [protein domain specific binding]
GO:0031201 [SNARE complex]
GO:0061025 [membrane fusion]
GO:0090158 [endoplasmic reticulum membrane organization]
GO:1902117 [positive regulation of organelle assembly]
GO:1902953 [positive regulation of ER to Golgi vesicle-mediated transport]
GO:1903358 [regulation of Golgi organization]
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 335 aa
38.7 kDa 		No 1
STX18-002
ENSP00000426648
ENST00000505286
D6RF48 [Direct mapping]
Syntaxin-18
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005484 [SNAP receptor activity]
GO:0006886 [intracellular protein transport]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0016020 [membrane]
GO:0031201 [SNARE complex]
GO:0061025 [membrane fusion]
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 308 aa
35.4 kDa 		No 0
STX18-004
ENSP00000422376
ENST00000507908
D6RC71 [Direct mapping]
Syntaxin-18
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005484 [SNAP receptor activity]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0031201 [SNARE complex]
GO:0061025 [membrane fusion]
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 169 aa
19.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.