Expression of ANKRD49 in cancer - Summary

GENERAL INFORMATION
Gene name	ANKRD49
Gene description	Ankyrin repeat domain 49
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in all tissues, additional cytoplasmic expression in some tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA040273
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable) and renal cancer (unfavourable).
Urothelial cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA040273

GENE INFORMATION
Gene name	ANKRD49 (HGNC Symbol)
Synonyms	FGIF, FLJ20189, GBIF
Description	Ankyrin repeat domain 49 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q21
Chromosome location (bp)	94493629 - 94499583
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168876 (version 83.38)
Entrez gene	54851
UniProt	Q8WVL7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WVL7
Antibodypedia	ANKRD49 antibodies

PROTEIN BROWSER

ANKRD49-001	ANKRD49-002	ANKRD49-004	ANKRD49-008	ANKRD49-009	ANKRD49-010	ANKRD49-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANKRD49-001 ENSP00000440396 ENST00000544612	Q8WVL7 [Direct mapping] Ankyrin repeat domain-containing protein 49 A0A024R398 [Target identity:100%; Query identity:100%] Ankyrin repeat domain 49, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007283 [spermatogenesis] GO:0030154 [cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	239 aa 27.3 kDa	No	0
ANKRD49-002 ENSP00000446433 ENST00000544253	F6R851 [Direct mapping] Ankyrin repeat domain-containing protein 49 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		125 aa 14.5 kDa	No	0
ANKRD49-004 ENSP00000303518 ENST00000302755	Q8WVL7 [Direct mapping] Ankyrin repeat domain-containing protein 49 A0A024R398 [Target identity:100%; Query identity:100%] Ankyrin repeat domain 49, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007283 [spermatogenesis] GO:0030154 [cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	239 aa 27.3 kDa	No	0
ANKRD49-008 ENSP00000442449 ENST00000535502	F5H7L0 [Direct mapping] Ankyrin repeat domain-containing protein 49 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	130 aa 14.6 kDa	No	0
ANKRD49-009 ENSP00000438506 ENST00000540349	F6R851 [Direct mapping] Ankyrin repeat domain-containing protein 49 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		125 aa 14.5 kDa	No	0
ANKRD49-010 ENSP00000441877 ENST00000545130	F5GWD9 [Direct mapping] Ankyrin repeat domain-containing protein 49 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		147 aa 17 kDa	No	0
ANKRD49-011 ENSP00000439200 ENST00000541144	F5H3B3 [Direct mapping] Ankyrin repeat domain-containing protein 49 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		111 aa 12.8 kDa	No	0