Expression of SFTPB in cancer - Summary - The Human Protein Atlas

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SFTPB

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SFTPB
Gene description	Surfactant protein B
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (lung cancer, thyroid cancer)
HPA (cell line):	Cell line enhanced (U-2197)
HPA (normal tissue):	Tissue enriched (lung)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in pneumocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA034820 , HPA062148 , CAB002440
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and renal cancer (unfavourable).
Endometrial cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (lung cancer, thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA034820	HPA062148	CAB002440

GENE INFORMATION
Gene name	SFTPB (HGNC Symbol)
Synonyms	SFTP3, SP-B
Description	Surfactant protein B (HGNC Symbol)
Entrez gene summary	This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, Feb 2010]
Chromosome	2
Cytoband	p11.2
Chromosome location (bp)	85657314 - 85668741
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168878 (version 83.38)
Entrez gene	6439
UniProt	P07988 (UniProt - Evidence at protein level)
neXtProt	NX_P07988
Antibodypedia	SFTPB antibodies

PROTEIN BROWSER

SFTPB-001	SFTPB-002	SFTPB-003	SFTPB-007	SFTPB-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SFTPB-001 ENSP00000428719 ENST00000519937	P07988 [Direct mapping] Pulmonary surfactant-associated protein B Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001664 [G-protein coupled receptor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005764 [lysosome] GO:0005771 [multivesicular body] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0006665 [sphingolipid metabolic process] GO:0007585 [respiratory gaseous exchange] GO:0008047 [enzyme activator activity] GO:0009887 [organ morphogenesis] GO:0042599 [lamellar body] GO:0043085 [positive regulation of catalytic activity] GO:0044267 [cellular protein metabolic process] GO:0045334 [clathrin-coated endocytic vesicle] GO:0097208 [alveolar lamellar body] GO:0097486 [multivesicular body lumen] Show all	381 aa 42.1 kDa	Yes	0
SFTPB-002 ENSP00000415347 ENST00000428225	H0Y7V6 [Direct mapping] Pulmonary surfactant-associated protein B Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005764 [lysosome] GO:0006629 [lipid metabolic process] GO:0006665 [sphingolipid metabolic process] Show all	374 aa 41.4 kDa	Yes	0
SFTPB-003 ENSP00000386346 ENST00000409383	D6W5L6 [Direct mapping] Pulmonary surfactant-associated protein B; Surfactant, pulmonary-associated protein B, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0006629 [lipid metabolic process] GO:0006665 [sphingolipid metabolic process] Show all	393 aa 43.3 kDa	Yes	0
SFTPB-007 ENSP00000476194 ENST00000494165	U3KQT2 [Direct mapping] Pulmonary surfactant-associated protein B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		92 aa 10 kDa	No	0
SFTPB-201 ENSP00000377409 ENST00000393822	P07988 [Direct mapping] Pulmonary surfactant-associated protein B Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001664 [G-protein coupled receptor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005764 [lysosome] GO:0005771 [multivesicular body] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0006665 [sphingolipid metabolic process] GO:0007585 [respiratory gaseous exchange] GO:0008047 [enzyme activator activity] GO:0009887 [organ morphogenesis] GO:0042599 [lamellar body] GO:0043085 [positive regulation of catalytic activity] GO:0044267 [cellular protein metabolic process] GO:0045334 [clathrin-coated endocytic vesicle] GO:0097208 [alveolar lamellar body] GO:0097486 [multivesicular body lumen] Show all	381 aa 42.1 kDa	Yes	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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