Expression of C2orf68 in cancer - Summary - The Human Protein Atlas

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C2orf68

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C2orf68
Gene description	Chromosome 2 open reading frame 68
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several cell types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA051143
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051143

GENE INFORMATION
Gene name	C2orf68
Synonyms
Description	Chromosome 2 open reading frame 68 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	p11.2
Chromosome location (bp)	85606654 - 85612066
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168887 (version 83.38)
Entrez gene	388969
UniProt	Q2NKX9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q2NKX9
Antibodypedia	C2orf68 antibodies

PROTEIN BROWSER

C2orf68-001	C2orf68-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C2orf68-001 ENSP00000304410 ENST00000306336	Q2NKX9 [Direct mapping] UPF0561 protein C2orf68 L7T9J5 [Target identity:100%; Query identity:100%] HCRCN81 protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all		166 aa 18.8 kDa	No	0
C2orf68-002 ENSP00000386301 ENST00000409734	Q2NKX9 [Direct mapping] UPF0561 protein C2orf68 Show all	Predicted intracellular proteins Show all		127 aa 14.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.