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Inositol polyphosphate-5-phosphatase D (HGNC Symbol)
Entrez gene summary
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004445 [inositol-polyphosphate 5-phosphatase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0006796 [phosphate-containing compound metabolic process] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0008285 [negative regulation of cell proliferation] GO:0008340 [determination of adult lifespan] GO:0009968 [negative regulation of signal transduction] GO:0016020 [membrane] GO:0016064 [immunoglobulin mediated immune response] GO:0017124 [SH3 domain binding] GO:0030853 [negative regulation of granulocyte differentiation] GO:0030889 [negative regulation of B cell proliferation] GO:0034594 [phosphatidylinositol trisphosphate phosphatase activity] GO:0035556 [intracellular signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] GO:0045409 [negative regulation of interleukin-6 biosynthetic process] GO:0045579 [positive regulation of B cell differentiation] GO:0045621 [positive regulation of lymphocyte differentiation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045656 [negative regulation of monocyte differentiation] GO:0045659 [negative regulation of neutrophil differentiation] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045779 [negative regulation of bone resorption] GO:0046856 [phosphatidylinositol dephosphorylation] GO:0050777 [negative regulation of immune response] GO:0050852 [T cell receptor signaling pathway] GO:0050869 [negative regulation of B cell activation] GO:0050900 [leukocyte migration] GO:0051425 [PTB domain binding]