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Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Caution, Splice and/or transcript discrepancy exists.
Malignant tissues displayed weak to moderate cytoplasmic and occasional nuclear positivity. Several cases of malignant melanomas, testicular, prostate and breast cancers were negative.
Fraction of cells in several cases of malignant gliomas, malignant lymphomas along with few cases of colorectal, endometrial, cervical, ovarian, pancreatic and prostate cancers showed moderate to strong cytoplasmic and nuclear positivity. Remaining cancer tissues were weakly stained or negative.
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]