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FEM1B

GENERAL INFORMATION

Gene name

 FEM1B

Gene description

 Fem-1 homolog b (C. elegans)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most cells, high levels in testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA041920 , HPA042192
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA041920
HPA042192

GENE INFORMATION

Gene name

 FEM1B

Synonyms

Description

 Fem-1 homolog b (C. elegans) (HGNC Symbol)

Entrez gene summary

 This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]

Chromosome

 15

Cytoband

 q23

Chromosome location (bp)

 68277803 - 68295865

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169018 (version 83.38)

Entrez gene

 10116

UniProt

 Q9UK73 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UK73

Antibodypedia

 FEM1B antibodies

PROTEIN BROWSER
FEM1B-001
FEM1B-002
FEM1B-003
FEM1B-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FEM1B-001
ENSP00000307298
ENST00000306917
Q9UK73 [Direct mapping]
Protein fem-1 homolog B
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002070 [epithelial cell maturation]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005123 [death receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0016567 [protein ubiquitination]
GO:0051438 [regulation of ubiquitin-protein transferase activity]
GO:0060442 [branching involved in prostate gland morphogenesis]
GO:0060743 [epithelial cell maturation involved in prostate gland development]
GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2000001 [regulation of DNA damage checkpoint]
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 627 aa
70.3 kDa 		No 0
FEM1B-002
ENSP00000457002
ENST00000570067
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 4 aa
0.4 kDa 		No 0
FEM1B-003
ENSP00000457342
ENST00000566739
H3BTV3 [Direct mapping]
Protein fem-1 homolog B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 80 aa
8.6 kDa 		No 0
FEM1B-004
ENSP00000456968
ENST00000566008
H3BT12 [Direct mapping]
Protein fem-1 homolog B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 269 aa
30.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.