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UQCRFS1

GENERAL INFORMATION

Gene name

 UQCRFS1

Gene description

 Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular expression in the cytoplasm of all cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA041863 , HPA050339
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), colorectal cancer (favourable) and ovarian cancer (unfavourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041863
HPA050339

GENE INFORMATION

Gene name

 UQCRFS1 (HGNC Symbol)

Synonyms

 RIP1, RIS1, RISP, UQCR5

Description

 Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 19

Cytoband

 q12

Chromosome location (bp)

 29205321 - 29213541

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169021 (version 83.38)

Entrez gene

 7386

UniProt

 P47985 (UniProt - Evidence at protein level)

neXtProt

 NX_P47985

Antibodypedia

 UQCRFS1 antibodies

PROTEIN BROWSER
UQCRFS1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UQCRFS1-001
ENSP00000306397
ENST00000304863
P47985 [Direct mapping]
Cytochrome b-c1 complex subunit Rieske, mitochondrial Cytochrome b-c1 complex subunit 11
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005750 [mitochondrial respiratory chain complex III]
GO:0008121 [ubiquinol-cytochrome-c reductase activity]
GO:0009725 [response to hormone]
GO:0016491 [oxidoreductase activity]
GO:0022904 [respiratory electron transport chain]
GO:0031966 [mitochondrial membrane]
GO:0032403 [protein complex binding]
GO:0042493 [response to drug]
GO:0043209 [myelin sheath]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046677 [response to antibiotic]
GO:0046872 [metal ion binding]
GO:0051537 [2 iron, 2 sulfur cluster binding]
GO:0055114 [oxidation-reduction process]
GO:1902600 [hydrogen ion transmembrane transport]
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 274 aa
29.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.