We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Cancer cells displayed weak to moderate cytoplasmic staining often combined with nuclear positivity. Liver, lung cancers and glioma were generally negative.
Most cancer tissues showed moderate cytoplasmic immunoreactivity. Strong staining was observed in a few lymphomas, testicular cancers and prostate cancers.
GENE INFORMATION
Gene name
MAP2K1 (HGNC Symbol)
Synonyms
MAPKK1, MEK1, PRKMK1
Description
Mitogen-activated protein kinase kinase 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]
Q02750 [Direct mapping] Dual specificity mitogen-activated protein kinase kinase 1 A4QPA9 [Target identity:100%; Query identity:100%] Mitogen-activated protein kinase kinase 1; Mitogen-activated protein kinase kinase 1, isoform CRA_a; cDNA FLJ76051, highly similar to Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNA
Show all
Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
H3BRW9 [Direct mapping] Dual-specificity mitogen-activated protein kinase kinase 1
Show all
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)