Tissue expression of KLK7 - Summary - The Human Protein Atlas

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KLK7

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TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	KLK7
Gene description	Kallikrein-related peptidase 7
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (esophagus, skin)
GTEx:	Tissue enhanced (esophagus, skin)
FANTOM5:	Tissue enhanced (esophagus, tonsil)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in the superficial layer of skin.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA062126 , CAB026342
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (esophagus, skin)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (esophagus, skin)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (esophagus, tonsil)

GENE INFORMATION
Gene name	KLK7 (HGNC Symbol)
Synonyms	PRSS6, SCCE
Description	Kallikrein-related peptidase 7 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]
Chromosome	19
Cytoband	q13.41
Chromosome location (bp)	50976482 - 50984099
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169035 (version 83.38)
Entrez gene	5650
UniProt	P49862 (UniProt - Evidence at protein level)
neXtProt	NX_P49862
Antibodypedia	KLK7 antibodies

PROTEIN BROWSER

KLK7-001	KLK7-003	KLK7-004	KLK7-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLK7-001 ENSP00000470538 ENST00000595820	P49862 [Direct mapping] Kallikrein-7 A0A024R4H6 [Target identity:100%; Query identity:100%] Kallikrein 7 (Chymotryptic, stratum corneum), isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0002803 [positive regulation of antibacterial peptide production] GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0008544 [epidermis development] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0097209 [epidermal lamellar body] Show all	253 aa 27.5 kDa	Yes	0
KLK7-003 ENSP00000469950 ENST00000597707	P49862 [Direct mapping] Kallikrein-7 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0002803 [positive regulation of antibacterial peptide production] GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0008544 [epidermis development] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0097209 [epidermal lamellar body] Show all	181 aa 19.9 kDa	No	0
KLK7-004 ENSP00000470084 ENST00000593904	M0QYU8 [Direct mapping] Kallikrein-7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	69 aa 7.8 kDa	No	0
KLK7-201 ENSP00000375683 ENST00000391807	P49862 [Direct mapping] Kallikrein-7 A0A024R4H6 [Target identity:100%; Query identity:100%] Kallikrein 7 (Chymotryptic, stratum corneum), isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0002803 [positive regulation of antibacterial peptide production] GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0008544 [epidermis development] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0097209 [epidermal lamellar body] Show all	253 aa 27.5 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.