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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ROR2
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ROR2

Gene description

Receptor tyrosine kinase-like orphan receptor 2

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (AF22, U-266/70, U-266/84)
HPA (normal tissue):Tissue enhanced (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA021868
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PROGNOSTIC SUMMARY

Prognostic marker in thyroid cancer (unfavourable) and renal cancer (unfavourable).
Thyroid cancer p<0.001
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA021868

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong cytoplasmic immunoreactivity, often with membranous positivity, was observed in most cancer tissues. Most renal tumors were negative.

GENE INFORMATION

Gene name

ROR2 (HGNC Symbol)

Synonyms

BDB, BDB1, NTRKR2

Description

Receptor tyrosine kinase-like orphan receptor 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q22.31

Chromosome location (bp)

91563091 - 91950162

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169071 (version 83.38)

Entrez gene

4920

UniProt

Q01974 (UniProt - Evidence at protein level)

neXtProt

NX_Q01974

Antibodypedia

ROR2 antibodies

PROTEIN BROWSER

ROR2-001
ROR2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ROR2-001
ENSP00000364860
ENST00000375708
Q01974 [Direct mapping]
Tyrosine-protein kinase transmembrane receptor ROR2
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001502 [cartilage condensation]
GO:0001756 [somitogenesis]
GO:0004672 [protein kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005109 [frizzled binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007223 [Wnt signaling pathway, calcium modulating pathway]
GO:0007224 [smoothened signaling pathway]
GO:0007254 [JNK cascade]
GO:0007275 [multicellular organismal development]
GO:0008285 [negative regulation of cell proliferation]
GO:0017147 [Wnt-protein binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030154 [cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0030509 [BMP signaling pathway]
GO:0030538 [embryonic genitalia morphogenesis]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0042472 [inner ear morphogenesis]
GO:0042733 [embryonic digit morphogenesis]
GO:0045165 [cell fate commitment]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0060395 [SMAD protein signal transduction]
GO:0060828 [regulation of canonical Wnt signaling pathway]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
943 aa
104.8 kDa
Yes 1
ROR2-002
ENSP00000364867
ENST00000375715
B1APY4 [Direct mapping]
Receptor tyrosine kinase-like orphan receptor 2, isoform CRA_b; Tyrosine-protein kinase transmembrane receptor ROR2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
704 aa
79.3 kDa
No 1

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