Expression of DHRSX in cancer - Summary - The Human Protein Atlas

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DHRSX

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DHRSX
Gene description	Dehydrogenase/reductase (SDR family) X-linked
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA003035
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003035

GENE INFORMATION
Gene name	DHRSX (HGNC Symbol)
Synonyms	DHRS5X, DHRS5Y, DHRSXY, DHRSY, SDR46C1, SDR7C6
Description	Dehydrogenase/reductase (SDR family) X-linked (HGNC Symbol)
Entrez gene summary
Chromosome	X
Cytoband	p22.33
Chromosome location (bp)	2219516 - 2502805
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169084 (version 83.38)
Entrez gene	207063
UniProt	Q8N5I4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N5I4
Antibodypedia	DHRSX antibodies

PROTEIN BROWSER

DHRSX-001	DHRSX-002	DHRSX-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DHRSX-001 ENSP00000334113 ENST00000334651	Q8N5I4 [Direct mapping] Dehydrogenase/reductase SDR family member on chromosome X Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	330 aa 36.4 kDa	No	0
DHRSX-002 ENSP00000402741 ENST00000444280	C9JRH1 [Direct mapping] Dehydrogenase/reductase SDR family member on chromosome X Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	122 aa 13.7 kDa	No	0
DHRSX-004 ENSP00000391778 ENST00000412516	C9JB06 [Direct mapping] Dehydrogenase/reductase SDR family member on chromosome X Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	232 aa 25.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.