Expression of PARM1 in cancer - Summary

GENERAL INFORMATION
Gene name	PARM1
Gene description	Prostate androgen-regulated mucin-like protein 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (Karpas-707, U-266/70)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues, most abundant in thyroid and gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA038236
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable).
Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA038236

GENE INFORMATION
Gene name	PARM1 (HGNC Symbol)
Synonyms	Cipar1, DKFZP564O0823, WSC4
Description	Prostate androgen-regulated mucin-like protein 1 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q13.3
Chromosome location (bp)	74933095 - 75050115
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169116 (version 83.38)
Entrez gene	25849
UniProt	Q6UWI2 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UWI2
Antibodypedia	PARM1 antibodies

PROTEIN BROWSER

PARM1-001	PARM1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PARM1-001 ENSP00000370224 ENST00000307428	Q6UWI2 [Direct mapping] Prostate androgen-regulated mucin-like protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0051973 [positive regulation of telomerase activity] Show all	310 aa 32.3 kDa	Yes	1
PARM1-002 ENSP00000424276 ENST00000513238	D6RBB6 [Direct mapping] Prostate androgen-regulated mucin-like protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	68 aa 7.5 kDa	No	1