Expression of FAM110B in cancer - Summary - The Human Protein Atlas

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FAM110B

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM110B
Gene description	Family with sequence similarity 110, member B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (RPTEC TERT1)
HPA (normal tissue):	Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA008318 , HPA011781
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable), renal cancer (favourable) and pancreatic cancer (favourable).
Endometrial cancer p<0.001 Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008318	HPA011781

GENE INFORMATION
Gene name	FAM110B (HGNC Symbol)
Synonyms	C8orf72, MGC39325
Description	Family with sequence similarity 110, member B (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	q12.1
Chromosome location (bp)	57994509 - 58204279
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169122 (version 83.38)
Entrez gene	90362
UniProt	Q8TC76 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TC76
Antibodypedia	FAM110B antibodies

PROTEIN BROWSER

FAM110B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM110B-001 ENSP00000355204 ENST00000361488	Q8TC76 [Direct mapping] Protein FAM110B A0A024R7V5 [Target identity:100%; Query identity:100%] Chromosome 8 open reading frame 72, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005815 [microtubule organizing center] Show all	370 aa 40.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.