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AFAP1L2

GENERAL INFORMATION

Gene name

 AFAP1L2

Gene description

 Actin filament associated protein 1-like 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Group enriched (A-431, CAPAN-2, EFO-21, HaCaT, hTCEpi, RPMI-8226, RPTEC TERT1)
HPA (normal tissue):Tissue enhanced (thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic positivity in connective tissue of spleen and thyroid gland

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Approved based on 1 antibody.
HPA037843
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA037843

GENE INFORMATION

Gene name

 AFAP1L2 (HGNC Symbol)

Synonyms

 Em:AC005383.4, FLJ14564, KIAA1914, XB130

Description

 Actin filament associated protein 1-like 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 10

Cytoband

 q25.3

Chromosome location (bp)

 114294824 - 114404756

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169129 (version 83.38)

Entrez gene

 84632

UniProt

 Q8N4X5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N4X5

Antibodypedia

 AFAP1L2 antibodies

PROTEIN BROWSER
AFAP1L2-001
AFAP1L2-002
AFAP1L2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AFAP1L2-001
ENSP00000358276
ENST00000369271
Q8N4X5 [Direct mapping]
Actin filament-associated protein 1-like 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007346 [regulation of mitotic cell cycle]
GO:0017124 [SH3 domain binding]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0032675 [regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0035591 [signaling adaptor activity]
GO:0042169 [SH2 domain binding]
GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
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 814 aa
90.9 kDa 		No 0
AFAP1L2-002
ENSP00000303042
ENST00000304129
Q8N4X5 [Direct mapping]
Actin filament-associated protein 1-like 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0007346 [regulation of mitotic cell cycle]
GO:0017124 [SH3 domain binding]
GO:0030296 [protein tyrosine kinase activator activity]
GO:0032675 [regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0035591 [signaling adaptor activity]
GO:0042169 [SH2 domain binding]
GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
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 818 aa
91.3 kDa 		No 0
AFAP1L2-006
ENSP00000396781
ENST00000419268
F6QUH3 [Direct mapping]
Actin filament-associated protein 1-like 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0009967 [positive regulation of signal transduction]
GO:0035591 [signaling adaptor activity]
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 312 aa
35.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.