Expression of MN1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MN1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MN1
Gene description	Meningioma (disrupted in balanced translocation) 1
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (AF22, RH-30, TIME, U-2 OS, U-2197)
HPA (normal tissue):	Tissue enhanced (skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA003072
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003072

GENE INFORMATION
Gene name	MN1 (HGNC Symbol)
Synonyms	MGCR, MGCR1, MGCR1-PEN
Description	Meningioma (disrupted in balanced translocation) 1 (HGNC Symbol)
Entrez gene summary	Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q12.1
Chromosome location (bp)	27748277 - 27801498
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169184 (version 83.38)
Entrez gene	4330
UniProt	Q10571 (UniProt - Evidence at protein level)
neXtProt	NX_Q10571
Antibodypedia	MN1 antibodies

PROTEIN BROWSER

MN1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MN1-001 ENSP00000304956 ENST00000302326	Q10571 [Direct mapping] Probable tumor suppressor protein MN1 A0A024R1C3 [Target identity:100%; Query identity:100%] Meningioma (Disrupted in balanced translocation) 1, isoform CRA_a Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001957 [intramembranous ossification] GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	1320 aa 136 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.