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APEX2

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GENERAL INFORMATION

Gene name

 APEX2

Gene description

 APEX nuclease (apurinic/apyrimidinic endonuclease) 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus & nucleoli (fibrillar center). In addition localized to vesicles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported), Nucleoli fibrillar center (supported)

Additional location

 In addition localized to the Vesicles (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA048577
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus & nucleoli (fibrillar center). In addition localized to vesicles.

Main location

 Nucleus (supported), Nucleoli fibrillar center (supported)

Additional location

 Vesicles (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA048577 A-431 Nucleus
Nucleoli fibrillar center
Vesicles
HPA048577 PC-3 Nucleus
Nucleoli fibrillar center
HPA048577 U-2 OS Nucleus
Nucleoli fibrillar center
Vesicles

GENE INFORMATION

Gene name

 APEX2 (HGNC Symbol)

Synonyms

 APE2, APEXL2, XTH2, ZGRF2

Description

 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (HGNC Symbol)

Entrez gene summary

 Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

Chromosome

 X

Cytoband

 p11.21

Chromosome location (bp)

 55000357 - 55009057

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169188 (version 83.38)

Entrez gene

 27301

UniProt

 Q9UBZ4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBZ4

Antibodypedia

 APEX2 antibodies

PROTEIN BROWSER
APEX2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APEX2-001
ENSP00000364126
ENST00000374987
Q9UBZ4 [Direct mapping]
DNA-(apurinic or apyrimidinic site) lyase 2
E5KN95 [Target identity:100%; Query identity:100%]
APEX nuclease (Apurinic/apyrimidinic endonuclease) 2, isoform CRA_b; DNA-apurinic or apyrimidinic site lyase 2
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Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity]
GO:0004518 [nuclease activity]
GO:0004519 [endonuclease activity]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006310 [DNA recombination]
GO:0007049 [cell cycle]
GO:0008270 [zinc ion binding]
GO:0008311 [double-stranded DNA 3'-5' exodeoxyribonuclease activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
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 518 aa
57.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.