Expression of THBS3 in cancer - Summary - The Human Protein Atlas

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THBS3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	THBS3
Gene description	Thrombospondin 3
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (SCLC-21H)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA006293
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (unfavourable) and colorectal cancer (unfavourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA006293

GENE INFORMATION
Gene name	THBS3
Synonyms
Description	Thrombospondin 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011]
Chromosome	1
Cytoband	q22
Chromosome location (bp)	155195588 - 155209051
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169231 (version 83.38)
Entrez gene	7059
UniProt	P49746 (UniProt - Evidence at protein level)
neXtProt	NX_P49746
Antibodypedia	THBS3 antibodies

PROTEIN BROWSER

THBS3-001	THBS3-009	THBS3-201	THBS3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
THBS3-001 ENSP00000357362 ENST00000368378	P49746 [Direct mapping] Thrombospondin-3 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003417 [growth plate cartilage development] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0008201 [heparin binding] GO:0043931 [ossification involved in bone maturation] GO:0048471 [perinuclear region of cytoplasm] GO:0060346 [bone trabecula formation] Show all	956 aa 104.2 kDa	Yes	0
THBS3-009 ENSP00000392207 ENST00000457183	P49746 [Direct mapping] Thrombospondin-3 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0008201 [heparin binding] GO:0048471 [perinuclear region of cytoplasm] Show all	836 aa 91.3 kDa	Yes	0
THBS3-201 ENSP00000444792 ENST00000541576	F5H4Z8 [Direct mapping] Thrombospondin-3 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007155 [cell adhesion] Show all	947 aa 103.3 kDa	Yes	0
THBS3-202 ENSP00000437353 ENST00000541990	Q2HIZ1 [Direct mapping] THBS3 protein; Thrombospondin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0007155 [cell adhesion] Show all	485 aa 53.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.