We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Cancer tissues displayed moderate to strong cytoplasmic positivity in a granular pattern. A few cases of squamous cell carcinomas and urothelial cancers were weakly stained.
GENE INFORMATION
Gene name
EFNA1 (HGNC Symbol)
Synonyms
ECKLG, EPLG1, LERK1, TNFAIP4
Description
Ephrin-A1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]