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CXCL10

GENERAL INFORMATION

Gene name

 CXCL10

Gene description

 Chemokine (C-X-C motif) ligand 10

Protein class

 Cancer-related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (appendix)
GTEx:Tissue enhanced (lung)
FANTOM5:Tissue enhanced (appendix)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix)

GENE INFORMATION

Gene name

 CXCL10 (HGNC Symbol)

Synonyms

 C7, crg-2, gIP-10, IFI10, INP10, IP-10, mob-1, SCYB10

Description

 Chemokine (C-X-C motif) ligand 10 (HGNC Symbol)

Entrez gene summary

 This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Sep 2014]

Chromosome

 4

Cytoband

 q21.1

Chromosome location (bp)

 76021117 - 76023497

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169245 (version 83.38)

Entrez gene

 3627

UniProt

 P02778 (UniProt - Evidence at protein level)

neXtProt

 NX_P02778

Antibodypedia

 CXCL10 antibodies

PROTEIN BROWSER
CXCL10-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CXCL10-001
ENSP00000305651
ENST00000306602
P02778 [Direct mapping]
C-X-C motif chemokine 10 CXCL10(1-73)
A0A024RDA4 [Target identity:100%; Query identity:100%]
C-X-C motif chemokine
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002690 [positive regulation of leukocyte chemotaxis]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007517 [muscle organ development]
GO:0008009 [chemokine activity]
GO:0008015 [blood circulation]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008603 [cAMP-dependent protein kinase regulator activity]
GO:0009409 [response to cold]
GO:0009615 [response to virus]
GO:0009897 [external side of plasma membrane]
GO:0010332 [response to gamma radiation]
GO:0010818 [T cell chemotaxis]
GO:0010819 [regulation of T cell chemotaxis]
GO:0010996 [response to auditory stimulus]
GO:0016525 [negative regulation of angiogenesis]
GO:0030335 [positive regulation of cell migration]
GO:0030816 [positive regulation of cAMP metabolic process]
GO:0032496 [response to lipopolysaccharide]
GO:0033280 [response to vitamin D]
GO:0034605 [cellular response to heat]
GO:0042118 [endothelial cell activation]
GO:0042127 [regulation of cell proliferation]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0045662 [negative regulation of myoblast differentiation]
GO:0045859 [regulation of protein kinase activity]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048248 [CXCR3 chemokine receptor binding]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051607 [defense response to virus]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:1901509 [regulation of endothelial tube morphogenesis]
GO:1901740 [negative regulation of myoblast fusion]
GO:2000406 [positive regulation of T cell migration]
Show all
 98 aa
10.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.