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ZRSR2

GENERAL INFORMATION

Gene name

 ZRSR2

Gene description

 Zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (favourable), urothelial cancer (favourable) and breast cancer (favourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
Urothelial cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 ZRSR2 (HGNC Symbol)

Synonyms

 U2AF1-RS2, U2AF1L2, URP, ZC3H22

Description

 Zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p22.2

Chromosome location (bp)

 15790472 - 15823260

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169249 (version 83.38)

Entrez gene

 8233

UniProt

 Q15696 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15696

Antibodypedia

 ZRSR2 antibodies

PROTEIN BROWSER
ZRSR2-001
ZRSR2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZRSR2-001
ENSP00000303015
ENST00000307771
Q15696 [Direct mapping]
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0000245 [spliceosomal complex assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005689 [U12-type spliceosomal complex]
GO:0008380 [RNA splicing]
GO:0030628 [pre-mRNA 3'-splice site binding]
GO:0046872 [metal ion binding]
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 482 aa
58 kDa 		No 0
ZRSR2-002
ENSP00000369664
ENST00000380308
A6NDW0 [Direct mapping]
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0005634 [nucleus]
Show all
 147 aa
17 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.