Expression of B3GALNT1 in cancer - Summary - The Human Protein Atlas

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B3GALNT1

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	B3GALNT1
Gene description	Beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
Protein class	Blood group antigen proteins Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (RT4)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	B3GALNT1 (HGNC Symbol)
Synonyms	B3GALT3, beta3Gal-T3, galT3, GLOB, P1
Description	Beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) (HGNC Symbol)
Entrez gene summary	This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). The encoded protein of this gene does not use N-acetylglucosamine as an acceptor sugar at all. Multiple transcript variants that are alternatively spliced in the 5' UTR have been described; they all encode the same protein. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q26.1
Chromosome location (bp)	161083883 - 161105384
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169255 (version 83.38)
Entrez gene	8706
UniProt	O75752 (UniProt - Evidence at transcript level)
neXtProt	NX_O75752
Antibodypedia	B3GALNT1 antibodies

PROTEIN BROWSER

B3GALNT1-001	B3GALNT1-002	B3GALNT1-003	B3GALNT1-004	B3GALNT1-005	B3GALNT1-006	B3GALNT1-007	B3GALNT1-010	B3GALNT1-012	B3GALNT1-013	B3GALNT1-014	B3GALNT1-015	B3GALNT1-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
B3GALNT1-001 ENSP00000376530 ENST00000392779	O75752 [Direct mapping] UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 Show all	Enzymes ENZYME proteins Transferases Blood group antigen proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0006486 [protein glycosylation] GO:0008378 [galactosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0047273 [galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity] Show all	331 aa 39.5 kDa	No	0
B3GALNT1-002 ENSP00000323479 ENST00000320474	O75752 [Direct mapping] UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 Show all	Enzymes ENZYME proteins Transferases Blood group antigen proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0006486 [protein glycosylation] GO:0008378 [galactosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0047273 [galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity] Show all	331 aa 39.5 kDa	No	0
B3GALNT1-003 ENSP00000376532 ENST00000392781	O75752 [Direct mapping] UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 Show all	Enzymes ENZYME proteins Transferases Blood group antigen proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0006486 [protein glycosylation] GO:0008378 [galactosyltransferase activity] GO:0008499 [UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity] GO:0009312 [oligosaccharide biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0047273 [galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity] Show all	331 aa 39.5 kDa	No	0
B3GALNT1-004 ENSP00000420163 ENST00000488170	O75752 [Direct mapping] UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 Show all	Enzymes ENZYME proteins Transferases Blood group antigen proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0006486 [protein glycosylation] GO:0008378 [galactosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0047273 [galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity] Show all	331 aa 39.5 kDa	No	0
B3GALNT1-005 ENSP00000418226 ENST00000473285	O75752 [Direct mapping] UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 Show all	Enzymes ENZYME proteins Transferases Blood group antigen proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0006486 [protein glycosylation] GO:0008378 [galactosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0047273 [galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity] Show all	331 aa 39.5 kDa	No	0
B3GALNT1-006 ENSP00000407027 ENST00000417187	E7EVF0 [Direct mapping] UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008378 [galactosyltransferase activity] GO:0016021 [integral component of membrane] Show all	91 aa 11 kDa	No	0
B3GALNT1-007 ENSP00000419127 ENST00000494173	C9JXR0 [Direct mapping] UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		29 aa 3.3 kDa	Yes	0
B3GALNT1-010 ENSP00000420059 ENST00000484127	C9JRV6 [Direct mapping] UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	41 aa 4.9 kDa	No	0
B3GALNT1-012 ENSP00000417643 ENST00000498216	C9J8U7 [Direct mapping] UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008378 [galactosyltransferase activity] GO:0016021 [integral component of membrane] Show all	54 aa 6.6 kDa	No	0
B3GALNT1-013 ENSP00000419476 ENST00000468268	E7EVS2 [Direct mapping] UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008378 [galactosyltransferase activity] GO:0016021 [integral component of membrane] Show all	111 aa 13.5 kDa	No	0
B3GALNT1-014 ENSP00000417053 ENST00000460353	C9J6I7 [Direct mapping] UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		150 aa 17.1 kDa	No	0
B3GALNT1-015 ENSP00000420604 ENST00000473142	C9JD16 [Direct mapping] UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008378 [galactosyltransferase activity] GO:0016021 [integral component of membrane] Show all	58 aa 7.1 kDa	No	0
B3GALNT1-016 ENSP00000418567 ENST00000492353	C9J0F8 [Direct mapping] UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006486 [protein glycosylation] GO:0008378 [galactosyltransferase activity] GO:0016021 [integral component of membrane] Show all	65 aa 8.1 kDa	No	0

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