Expression of GPRIN1 in cancer - Summary - The Human Protein Atlas

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GPRIN1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GPRIN1
Gene description	G protein regulated inducer of neurite outgrowth 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HDLM-2, SCLC-21H)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression mainly in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA070892
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA070892

GENE INFORMATION
Gene name	GPRIN1 (HGNC Symbol)
Synonyms	GRIN1, KIAA1893
Description	G protein regulated inducer of neurite outgrowth 1 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q35.2
Chromosome location (bp)	176595802 - 176610133
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169258 (version 83.38)
Entrez gene	114787
UniProt	Q7Z2K8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q7Z2K8
Antibodypedia	GPRIN1 antibodies

PROTEIN BROWSER

GPRIN1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPRIN1-001 ENSP00000305839 ENST00000303991	Q7Z2K8 [Direct mapping] G protein-regulated inducer of neurite outgrowth 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0030426 [growth cone] GO:0031175 [neuron projection development] GO:0051219 [phosphoprotein binding] Show all	1008 aa 102.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.