Cell atlas - HSPB3 - The Human Protein Atlas

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HSPB3

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	HSPB3
Gene description	Heat shock 27kDa protein 3
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles.
RNA cell category	Cell line enriched (BJ hTERT+)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA062124
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (BJ hTERT+) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles.

Main location

Nuclear speckles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA062124	HaCaT	Nuclear speckles
	HPA062124	HeLa	Nuclear speckles
	HPA062124	U-2 OS	Nuclear speckles

GENE INFORMATION
Gene name	HSPB3 (HGNC Symbol)
Synonyms	HSPL27
Description	Heat shock 27kDa protein 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a muscle-specific small heat shock protein. A mutation in this gene is the cause of autosomal dominant distal hereditary motor neuropathy type 2C.[provided by RefSeq, Sep 2010]
Chromosome	5
Cytoband	q11.2
Chromosome location (bp)	54455601 - 54456384
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169271 (version 83.38)
Entrez gene	8988
UniProt	Q12988 (UniProt - Evidence at protein level)
neXtProt	NX_Q12988
Antibodypedia	HSPB3 antibodies

PROTEIN BROWSER

HSPB3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HSPB3-001 ENSP00000303394 ENST00000302005	Q12988 [Direct mapping] Heat shock protein beta-3 Q6ICS9 [Target identity:100%; Query identity:100%] HSPB3 protein; Heat shock 27kDa protein 3; cDNA, FLJ94950, Homo sapiens heat shock 27kDa protein 3 (HSPB3), mRNA Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006986 [response to unfolded protein] Show all	150 aa 17 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.