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MRPL1

GENERAL INFORMATION

Gene name

 MRPL1

Gene description

 Mitochondrial ribosomal protein L1

Protein class

 Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA043656
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043656

GENE INFORMATION

Gene name

 MRPL1 (HGNC Symbol)

Synonyms

 BM022

Description

 Mitochondrial ribosomal protein L1 (HGNC Symbol)

Entrez gene summary

 Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q21.1

Chromosome location (bp)

 77862520 - 77952790

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169288 (version 83.38)

Entrez gene

 65008

UniProt

 Q9BYD6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BYD6

Antibodypedia

 MRPL1 antibodies

PROTEIN BROWSER
MRPL1-001
MRPL1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MRPL1-001
ENSP00000315017
ENST00000315567
Q9BYD6 [Direct mapping]
39S ribosomal protein L1, mitochondrial
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Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0015934 [large ribosomal subunit]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
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 325 aa
36.9 kDa 		No 0
MRPL1-002
ENSP00000421616
ENST00000502384
H0Y8N7 [Direct mapping]
39S ribosomal protein L1, mitochondrial
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   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0003735 [structural constituent of ribosome]
GO:0005739 [mitochondrion]
GO:0006412 [translation]
GO:0015934 [large ribosomal subunit]
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 231 aa
26.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.