Tissue expression of IL1RAPL1 - Summary

GENERAL INFORMATION
Gene name	IL1RAPL1
Gene description	Interleukin 1 receptor accessory protein-like 1
Protein class	Disease related genes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Tissue enhanced (hippocampus)
FANTOM5:	Tissue enhanced (brain, caudate, cerebellum, hippocampus)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (hippocampus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (brain, caudate, cerebellum, hippocampus)

GENE INFORMATION
Gene name	IL1RAPL1 (HGNC Symbol)
Synonyms	IL1R8, IL1RAPL, MRX10, MRX21, MRX34, OPHN4, TIGIRR-2
Description	Interleukin 1 receptor accessory protein-like 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband
Chromosome location (bp)	28587399 - 29956723
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169306 (version 83.38)
Entrez gene	11141
UniProt	Q9NZN1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NZN1
Antibodypedia	IL1RAPL1 antibodies

PROTEIN BROWSER

IL1RAPL1-001	IL1RAPL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL1RAPL1-001 ENSP00000368278 ENST00000378993	Q9NZN1 [Direct mapping] Interleukin-1 receptor accessory protein-like 1 X5DNQ7 [Target identity:100%; Query identity:100%] Interleukin 1 receptor accessory protein-like 1 isoform A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005102 [receptor binding] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007165 [signal transduction] GO:0009986 [cell surface] GO:0010975 [regulation of neuron projection development] GO:0016021 [integral component of membrane] GO:0030182 [neuron differentiation] GO:0030424 [axon] GO:0030425 [dendrite] GO:0045211 [postsynaptic membrane] GO:0045920 [negative regulation of exocytosis] GO:0050775 [positive regulation of dendrite morphogenesis] GO:0070588 [calcium ion transmembrane transport] GO:0097105 [presynaptic membrane assembly] Show all	696 aa 80 kDa	Yes	1
IL1RAPL1-201 ENSP00000305200 ENST00000302196	A0A0A0MR17 [Direct mapping] Interleukin-1 receptor accessory protein-like 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] Show all	437 aa 50.2 kDa	No	1