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Malignant cells showed weak to moderate cytoplasmic immunoreactivity often with a granular pattern. All non-Hodgkin’s lymphomas were strongly stained whereas Hodgkin’s lymphomas, lung, skin, testicular and hepatocellular hepatocellular cancers were weakly stained or negative.
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]