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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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P2RY12
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

P2RY12

Gene description

Purinergic receptor P2Y, G-protein coupled, 12

Protein class

Disease related genes
FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic and nuclear expression in microglia and subsets of cells in bone marrow and lymphoid tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA013796 , HPA014518
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA013796
HPA014518

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant cells showed weak to moderate cytoplasmic immunoreactivity often with a granular pattern. All non-Hodgkin’s lymphomas were strongly stained whereas Hodgkin’s lymphomas, lung, skin, testicular and hepatocellular hepatocellular cancers were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues were negative.

GENE INFORMATION

Gene name

P2RY12 (HGNC Symbol)

Synonyms

HORK3, P2Y12, SP1999

Description

Purinergic receptor P2Y, G-protein coupled, 12 (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Chromosome

3

Cytoband

q25.1

Chromosome location (bp)

151337380 - 151384812

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169313 (version 83.38)

Entrez gene

64805

UniProt

Q9H244 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H244

Antibodypedia

P2RY12 antibodies

PROTEIN BROWSER

P2RY12-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

P2RY12-001
ENSP00000307259
ENST00000302632
Q9H244 [Direct mapping]
P2Y purinoceptor 12
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Adenosine and adenine nucleotide receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001609 [G-protein coupled adenosine receptor activity]
GO:0001621 [ADP receptor activity]
GO:0001973 [adenosine receptor signaling pathway]
GO:0004930 [G-protein coupled receptor activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0006930 [substrate-dependent cell migration, cell extension]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0007599 [hemostasis]
GO:0008347 [glial cell migration]
GO:0009897 [external side of plasma membrane]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010700 [negative regulation of norepinephrine secretion]
GO:0016021 [integral component of membrane]
GO:0030030 [cell projection organization]
GO:0030168 [platelet activation]
GO:0031224 [intrinsic component of membrane]
GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway]
GO:0043270 [positive regulation of ion transport]
GO:0043491 [protein kinase B signaling]
GO:0043547 [positive regulation of GTPase activity]
GO:0045596 [negative regulation of cell differentiation]
GO:0051924 [regulation of calcium ion transport]
GO:0070527 [platelet aggregation]
GO:0070588 [calcium ion transmembrane transport]
GO:0071318 [cellular response to ATP]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071805 [potassium ion transmembrane transport]
GO:1904139 [regulation of microglial cell migration]
Show all
342 aa
39.4 kDa
No 7

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