Expression of CRADD in cancer - Summary - The Human Protein Atlas

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CRADD

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CRADD
Gene description	CASP2 and RIPK1 domain containing adaptor with death domain
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. CAB005337
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and cervical cancer (favourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB005337

GENE INFORMATION
Gene name	CRADD (HGNC Symbol)
Synonyms	RAIDD
Description	CASP2 and RIPK1 domain containing adaptor with death domain (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q22
Chromosome location (bp)	93677375 - 93894840
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169372 (version 83.38)
Entrez gene	8738
UniProt	P78560 (UniProt - Evidence at protein level)
neXtProt	NX_P78560
Antibodypedia	CRADD antibodies

PROTEIN BROWSER

CRADD-001	CRADD-002	CRADD-003	CRADD-005	CRADD-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRADD-001 ENSP00000327647 ENST00000332896	P78560 [Direct mapping] Death domain-containing protein CRADD Q53XL1 [Target identity:100%; Query identity:100%] CASP2 and RIPK1 domain containing adaptor with death domain; CRADD protein; cDNA, FLJ95760, Homo sapiens CASP2 and RIPK1 domain containing adaptor with deathdomain (CRADD), mRNA Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007165 [signal transduction] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0030674 [protein binding, bridging] GO:0042981 [regulation of apoptotic process] GO:0070513 [death domain binding] GO:0071260 [cellular response to mechanical stimulus] Show all	199 aa 22.7 kDa	No	0
CRADD-002 ENSP00000439068 ENST00000542893	P78560 [Direct mapping] Death domain-containing protein CRADD Q53XL1 [Target identity:100%; Query identity:100%] CASP2 and RIPK1 domain containing adaptor with death domain; CRADD protein; cDNA, FLJ95760, Homo sapiens CASP2 and RIPK1 domain containing adaptor with deathdomain (CRADD), mRNA Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007165 [signal transduction] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0030674 [protein binding, bridging] GO:0042981 [regulation of apoptotic process] GO:0070513 [death domain binding] GO:0071260 [cellular response to mechanical stimulus] GO:2001235 [positive regulation of apoptotic signaling pathway] Show all	199 aa 22.7 kDa	No	0
CRADD-003 ENSP00000448685 ENST00000548483	F5H7C2 [Direct mapping] Death domain-containing protein CRADD Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0042981 [regulation of apoptotic process] Show all	121 aa 14 kDa	No	0
CRADD-005 ENSP00000449664 ENST00000552033	F8VV49 [Direct mapping] Death domain-containing protein CRADD Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0042981 [regulation of apoptotic process] Show all	115 aa 13.2 kDa	No	0
CRADD-007 ENSP00000449570 ENST00000552983	F8VVY5 [Direct mapping] Death domain-containing protein CRADD Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0042981 [regulation of apoptotic process] Show all	130 aa 14.8 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.