Fields »
ABOUT
HELP
BLOG
RNASE2

GENERAL INFORMATION

Gene name

 RNASE2

Gene description

 Ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)

Protein class

 Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Group enriched (HL-60, NB-4, THP-1, U-937)
HPA (normal tissue):Tissue enriched (bone marrow)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in bone marrow, spleen and in a subset of inflammatory cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA044983
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044983

GENE INFORMATION

Gene name

 RNASE2 (HGNC Symbol)

Synonyms

 EDN, RAF3, RNS2

Description

 Ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses. [provided by RefSeq, Oct 2014]

Chromosome

 14

Cytoband

 q11.2

Chromosome location (bp)

 20955452 - 20956436

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169385 (version 83.38)

Entrez gene

 6036

UniProt

 P10153 (UniProt - Evidence at protein level)

neXtProt

 NX_P10153

Antibodypedia

 RNASE2 antibodies

PROTEIN BROWSER
RNASE2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RNASE2-001
ENSP00000303276
ENST00000304625
P10153 [Direct mapping]
Non-secretory ribonuclease
W0UV60 [Target identity:100%; Query identity:100%]
Ribonuclease A F3; Ribonuclease, RNase A family, 2 (Liver, eosinophil-derived neurotoxin)
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004519 [endonuclease activity]
GO:0004522 [ribonuclease A activity]
GO:0004540 [ribonuclease activity]
GO:0005576 [extracellular region]
GO:0005764 [lysosome]
GO:0006401 [RNA catabolic process]
GO:0006935 [chemotaxis]
GO:0070062 [extracellular exosome]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 161 aa
18.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.