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RNASE3

GENERAL INFORMATION

Gene name

 RNASE3

Gene description

 Ribonuclease, RNase A family, 3

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Cell line enhanced (HL-60, THP-1, U-937)
HPA (normal tissue):Tissue enriched (bone marrow)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Expression in a subset of hematopoietic cells and peripheral leukocytes

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA056183
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA056183

GENE INFORMATION

Gene name

 RNASE3 (HGNC Symbol)

Synonyms

 ECP, RAF1, RNS3

Description

 Ribonuclease, RNase A family, 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014]

Chromosome

 14

Cytoband

 q11.2

Chromosome location (bp)

 20891399 - 20892348

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169397 (version 83.38)

Entrez gene

 6037

UniProt

 P12724 (UniProt - Evidence at protein level)

neXtProt

 NX_P12724

Antibodypedia

 RNASE3 antibodies

PROTEIN BROWSER
RNASE3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RNASE3-001
ENSP00000302324
ENST00000304639
P12724 [Direct mapping]
Eosinophil cationic protein
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002227 [innate immune response in mucosa]
GO:0003676 [nucleic acid binding]
GO:0004519 [endonuclease activity]
GO:0004540 [ribonuclease activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006401 [RNA catabolic process]
GO:0019731 [antibacterial humoral response]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070062 [extracellular exosome]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0090501 [RNA phosphodiester bond hydrolysis]
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 160 aa
18.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.