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PTK2

GENERAL INFORMATION

Gene name

 PTK2

Gene description

 Protein tyrosine kinase 2

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 33
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA001842 , CAB004036
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable) and endometrial cancer (unfavourable).
Breast cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001842
CAB004036

GENE INFORMATION

Gene name

 PTK2 (HGNC Symbol)

Synonyms

 FADK, FAK, FAK1, PPP1R71

Description

 Protein tyrosine kinase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only four of them have been determined. [provided by RefSeq, Oct 2015]

Chromosome

 8

Cytoband

 q24.3

Chromosome location (bp)

 140657900 - 141002216

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169398 (version 83.38)

Entrez gene

 5747

UniProt

 Q05397 (UniProt - Evidence at protein level)

neXtProt

 NX_Q05397

Antibodypedia

 PTK2 antibodies

PROTEIN BROWSER
«
PTK2-001
PTK2-002
PTK2-004
PTK2-005
PTK2-006
PTK2-007
PTK2-008
PTK2-009
PTK2-010
PTK2-011
PTK2-014
PTK2-015
PTK2-019
PTK2-020
PTK2-032
PTK2-033
PTK2-034
PTK2-035
PTK2-037
PTK2-038
PTK2-039
PTK2-040
PTK2-041
PTK2-042
PTK2-043
PTK2-044
PTK2-045
PTK2-047
PTK2-053
PTK2-054
PTK2-055
PTK2-057
PTK2-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTK2-001
ENSP00000429911
ENST00000522684
Q05397 [Direct mapping]
Focal adhesion kinase 1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001725 [stress fiber]
GO:0001890 [placenta development]
GO:0001932 [regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003007 [heart morphogenesis]
GO:0003779 [actin binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0008432 [JUN kinase binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009790 [embryo development]
GO:0010594 [regulation of endothelial cell migration]
GO:0010632 [regulation of epithelial cell migration]
GO:0012501 [programmed cell death]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030010 [establishment of cell polarity]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0038007 [netrin-activated signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell proliferation]
GO:0042169 [SH2 domain binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048870 [cell motility]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051893 [regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060396 [growth hormone receptor signaling pathway]
GO:1900024 [regulation of substrate adhesion-dependent cell spreading]
GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000811 [negative regulation of anoikis]
Show all
 1052 aa
119.2 kDa 		No 0
PTK2-002
ENSP00000428492
ENST00000523539
H0YB16 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0005524 [ATP binding]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 724 aa
81.5 kDa 		No 0
PTK2-004
ENSP00000430916
ENST00000517712
E5RHD8 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004713 [protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 115 aa
12.9 kDa 		No 0
PTK2-005
ENSP00000429170
ENST00000519465
E9PEI4 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0005524 [ATP binding]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 680 aa
76.8 kDa 		No 0
PTK2-006
ENSP00000403416
ENST00000430260
B4DWJ1 [Direct mapping]
Focal adhesion kinase 1; cDNA FLJ57218, highly similar to Focal adhesion kinase 1 (EC 2.7.10.2)
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004713 [protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 362 aa
40.2 kDa 		No 0
PTK2-007
ENSP00000429129
ENST00000519419
E7ESA6 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 1096 aa
124.1 kDa 		No 0
PTK2-008
ENSP00000429082
ENST00000517887
E7ESA6 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 1096 aa
124.1 kDa 		No 0
PTK2-009
ENSP00000430603
ENST00000521986
H0YBZ1 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0005524 [ATP binding]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 753 aa
84.8 kDa 		No 0
PTK2-010
ENSP00000429929
ENST00000519654
H0YBP1 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0005524 [ATP binding]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 1017 aa
115.4 kDa 		No 0
PTK2-011
ENSP00000341189
ENST00000340930
Q05397 [Direct mapping]
Focal adhesion kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000226 [microtubule cytoskeleton organization]
GO:0001525 [angiogenesis]
GO:0001568 [blood vessel development]
GO:0001570 [vasculogenesis]
GO:0001725 [stress fiber]
GO:0001764 [neuron migration]
GO:0001890 [placenta development]
GO:0001932 [regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003007 [heart morphogenesis]
GO:0003779 [actin binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0008432 [JUN kinase binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009790 [embryo development]
GO:0010594 [regulation of endothelial cell migration]
GO:0010632 [regulation of epithelial cell migration]
GO:0012501 [programmed cell death]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016324 [apical plasma membrane]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0021955 [central nervous system neuron axonogenesis]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030010 [establishment of cell polarity]
GO:0030027 [lamellipodium]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0038007 [netrin-activated signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0040023 [establishment of nucleus localization]
GO:0042127 [regulation of cell proliferation]
GO:0042169 [SH2 domain binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043542 [endothelial cell migration]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046621 [negative regulation of organ growth]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048870 [cell motility]
GO:0050771 [negative regulation of axonogenesis]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051893 [regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051964 [negative regulation of synapse assembly]
GO:0060396 [growth hormone receptor signaling pathway]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:1900024 [regulation of substrate adhesion-dependent cell spreading]
GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000811 [negative regulation of anoikis]
Show all
 1065 aa
120.9 kDa 		No 0
PTK2-014
ENSP00000429437
ENST00000522950
E5RII9 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 67 aa
7.6 kDa 		No 0
PTK2-015
ENSP00000430828
ENST00000523435
E5RI03 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004713 [protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 120 aa
13.7 kDa 		No 0
PTK2-019
ENSP00000431106
ENST00000521562
E5RJQ2 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 132 aa
14.8 kDa 		No 0
PTK2-020
ENSP00000429702
ENST00000523388
E5RHK7 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 67 aa
7.3 kDa 		No 0
PTK2-032
ENSP00000429530
ENST00000523803
E5RI72 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 120 aa
13.7 kDa 		No 0
PTK2-033
ENSP00000428792
ENST00000520475
E5RGA6 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 156 aa
18.2 kDa 		No 0
PTK2-034
ENSP00000429907
ENST00000521395
E5RH48 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 107 aa
12 kDa 		No 0
PTK2-035
ENSP00000427795
ENST00000521907
E5RG66 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 119 aa
13.5 kDa 		No 0
PTK2-037
ENSP00000430277
ENST00000519881
E5RFW9 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 121 aa
13.8 kDa 		No 0
PTK2-038
ENSP00000427904
ENST00000520892
E5RFW9 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 121 aa
13.8 kDa 		No 0
PTK2-039
ENSP00000429409
ENST00000521332
E5RIK4 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 65 aa
7.2 kDa 		No 0
PTK2-040
ENSP00000429028
ENST00000523679
E5RJN1 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 15 aa
1.5 kDa 		No 0
PTK2-041
ENSP00000427762
ENST00000520828
E5RG86 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 59 aa
7.2 kDa 		No 0
PTK2-042
ENSP00000431023
ENST00000524257
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 8 aa
0.9 kDa 		No 0
PTK2-043
ENSP00000430951
ENST00000517453
E5RH01 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 117 aa
13.2 kDa 		No 0
PTK2-044
ENSP00000430044
ENST00000520045
E5RH01 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 117 aa
13.2 kDa 		No 0
PTK2-045
ENSP00000430037
ENST00000524040
E5RH08 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 51 aa
5.6 kDa 		No 0
PTK2-047
ENSP00000427774
ENST00000522424
E5RG80 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 133 aa
15 kDa 		No 0
PTK2-053
ENSP00000428232
ENST00000519024
E5RJI4 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 169 aa
19.3 kDa 		No 0
PTK2-054
ENSP00000428482
ENST00000520151
E5RI29 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005102 [receptor binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 124 aa
14 kDa 		No 0
PTK2-055
ENSP00000429001
ENST00000524357
E5RJP0 [Direct mapping]
Focal adhesion kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
Show all
 122 aa
13.8 kDa 		No 0
PTK2-057
ENSP00000429474
ENST00000521059
Q05397 [Direct mapping]
Focal adhesion kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001725 [stress fiber]
GO:0001890 [placenta development]
GO:0001932 [regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003007 [heart morphogenesis]
GO:0003779 [actin binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0008432 [JUN kinase binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009790 [embryo development]
GO:0010594 [regulation of endothelial cell migration]
GO:0010632 [regulation of epithelial cell migration]
GO:0012501 [programmed cell death]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030010 [establishment of cell polarity]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0038007 [netrin-activated signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell proliferation]
GO:0042169 [SH2 domain binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048870 [cell motility]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051893 [regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060396 [growth hormone receptor signaling pathway]
GO:1900024 [regulation of substrate adhesion-dependent cell spreading]
GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000811 [negative regulation of anoikis]
Show all
 1052 aa
119.2 kDa 		No 0
PTK2-201
ENSP00000378644
ENST00000395218
Q05397 [Direct mapping]
Focal adhesion kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001725 [stress fiber]
GO:0001890 [placenta development]
GO:0001932 [regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003007 [heart morphogenesis]
GO:0003779 [actin binding]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0007010 [cytoskeleton organization]
GO:0007155 [cell adhesion]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0008432 [JUN kinase binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009790 [embryo development]
GO:0010594 [regulation of endothelial cell migration]
GO:0010632 [regulation of epithelial cell migration]
GO:0012501 [programmed cell death]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030010 [establishment of cell polarity]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030335 [positive regulation of cell migration]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0033628 [regulation of cell adhesion mediated by integrin]
GO:0038007 [netrin-activated signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell proliferation]
GO:0042169 [SH2 domain binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043087 [regulation of GTPase activity]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045087 [innate immune response]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048870 [cell motility]
GO:0051493 [regulation of cytoskeleton organization]
GO:0051893 [regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060396 [growth hormone receptor signaling pathway]
GO:1900024 [regulation of substrate adhesion-dependent cell spreading]
GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:2000811 [negative regulation of anoikis]
Show all
 1006 aa
114.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.