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Malignant cells showed moderate to strong cytoplasmic and membranous staining. Malignant gliomas and lymphomas were generally negative.
GENE INFORMATION
Gene name
PTPN9 (HGNC Symbol)
Synonyms
MEG2
Description
Protein tyrosine phosphatase, non-receptor type 9 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. [provided by RefSeq, Jul 2008]