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NPR1

GENERAL INFORMATION

Gene name

 NPR1

Gene description

 Natriuretic peptide receptor 1

Protein class

 Enzymes
FDA approved drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (adipose tissue, fallopian tube)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue, fallopian tube)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NPR1 (HGNC Symbol)

Synonyms

 ANPa, ANPRA, GUCY2A, NPRA

Description

 Natriuretic peptide receptor 1 (HGNC Symbol)

Entrez gene summary

 Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 153678637 - 153693992

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000169418 (version 83.38)

Entrez gene

 4881

UniProt

 P16066 (UniProt - Evidence at protein level)

neXtProt

 NX_P16066

Antibodypedia

 NPR1 antibodies

PROTEIN BROWSER
NPR1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NPR1-001
ENSP00000357669
ENST00000368680
P16066 [Direct mapping]
Atrial natriuretic peptide receptor 1
Show all
Enzymes
   ENZYME proteins
   Lyases
   Kinases
   RGC receptor guanylate cyclase kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004383 [guanylate cyclase activity]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006182 [cGMP biosynthetic process]
GO:0006468 [protein phosphorylation]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007168 [receptor guanylyl cyclase signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007589 [body fluid secretion]
GO:0008074 [guanylate cyclase complex, soluble]
GO:0008217 [regulation of blood pressure]
GO:0008528 [G-protein coupled peptide receptor activity]
GO:0009190 [cyclic nucleotide biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0016849 [phosphorus-oxygen lyase activity]
GO:0016941 [natriuretic peptide receptor activity]
GO:0017046 [peptide hormone binding]
GO:0019901 [protein kinase binding]
GO:0030308 [negative regulation of cell growth]
GO:0030828 [positive regulation of cGMP biosynthetic process]
GO:0035556 [intracellular signal transduction]
GO:0035810 [positive regulation of urine volume]
GO:0035815 [positive regulation of renal sodium excretion]
GO:0042312 [regulation of vasodilation]
GO:0042417 [dopamine metabolic process]
GO:0042562 [hormone binding]
GO:0043114 [regulation of vascular permeability]
GO:0043235 [receptor complex]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0050880 [regulation of blood vessel size]
Show all
 1061 aa
118.9 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.